A Missing Link to Vitamin B12 Metabolism.
Journal Article (Journal Article)
Nearly 3% of the human population carries bi-allelic loss-of-function variants in the gene encoding CLYBL. While largely healthy, these individuals exhibit reduced circulating vitamin B12 levels. In this issue of Cell, Shen and colleagues uncover the metabolic role of CLYBL, linking its function to B12 metabolism and the immunomodulatory metabolite, itaconate.
Full Text
Duke Authors
Cited Authors
- Reid, MA; Paik, J; Locasale, JW
Published Date
- November 2, 2017
Published In
Volume / Issue
- 171 / 4
Start / End Page
- 736 - 737
PubMed ID
- 29100069
Electronic International Standard Serial Number (EISSN)
- 1097-4172
Digital Object Identifier (DOI)
- 10.1016/j.cell.2017.10.030
Language
- eng
Conference Location
- United States