A Missing Link to Vitamin B12 Metabolism.

Journal Article (Journal Article)

Nearly 3% of the human population carries bi-allelic loss-of-function variants in the gene encoding CLYBL. While largely healthy, these individuals exhibit reduced circulating vitamin B12 levels. In this issue of Cell, Shen and colleagues uncover the metabolic role of CLYBL, linking its function to B12 metabolism and the immunomodulatory metabolite, itaconate.

Full Text

Duke Authors

Cited Authors

  • Reid, MA; Paik, J; Locasale, JW

Published Date

  • November 2, 2017

Published In

Volume / Issue

  • 171 / 4

Start / End Page

  • 736 - 737

PubMed ID

  • 29100069

Electronic International Standard Serial Number (EISSN)

  • 1097-4172

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2017.10.030


  • eng

Conference Location

  • United States