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Power spectral analysis of hypoglossal nerve activity during intermittent hypoxia-induced long-term facilitation in mice.

Publication ,  Journal Article
ElMallah, MK; Stanley, DA; Lee, K-Z; Turner, SMF; Streeter, KA; Baekey, DM; Fuller, DD
Published in: J Neurophysiol
March 2016

Power spectral analyses of electrical signals from respiratory nerves reveal prominent oscillations above the primary rate of breathing. Acute exposure to intermittent hypoxia can induce a form of neuroplasticity known as long-term facilitation (LTF), in which inspiratory burst amplitude is persistently elevated. Most evidence indicates that the mechanisms of LTF are postsynaptic and also that high-frequency oscillations within the power spectrum show coherence across different respiratory nerves. Since the most logical interpretation of this coherence is that a shared presynaptic mechanism is responsible, we hypothesized that high-frequency spectral content would be unchanged during LTF. Recordings of inspiratory hypoglossal (XII) activity were made from anesthetized, vagotomized, and ventilated 129/SVE mice. When arterial O2 saturation (SaO2) was maintained >96%, the XII power spectrum and burst amplitude were unchanged for 90 min. Three, 1-min hypoxic episodes (SaO2 = 50 ± 10%), however, caused a persistent (>60 min) and robust (>400% baseline) increase in burst amplitude. Spectral analyses revealed a rightward shift of the signal content during LTF, with sustained increases in content above ∼125 Hz following intermittent hypoxia and reductions in power at lower frequencies. Changes in the spectral content during LTF were qualitatively similar to what occurred during the acute hypoxic response. We conclude that high-frequency content increases during XII LTF in this experimental preparation; this may indicate that intermittent hypoxia-induced plasticity in the premotor network contributes to expression of XII LTF.

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Published In

J Neurophysiol

DOI

EISSN

1522-1598

Publication Date

March 2016

Volume

115

Issue

3

Start / End Page

1372 / 1380

Location

United States

Related Subject Headings

  • Synaptic Potentials
  • Neurology & Neurosurgery
  • Mice
  • Male
  • Long-Term Potentiation
  • Hypoxia
  • Hypoglossal Nerve
  • Animals
  • 52 Psychology
  • 42 Health sciences
 

Citation

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ElMallah, M. K., Stanley, D. A., Lee, K.-Z., Turner, S. M. F., Streeter, K. A., Baekey, D. M., & Fuller, D. D. (2016). Power spectral analysis of hypoglossal nerve activity during intermittent hypoxia-induced long-term facilitation in mice. J Neurophysiol, 115(3), 1372–1380. https://doi.org/10.1152/jn.00479.2015
ElMallah, Mai K., David A. Stanley, Kun-Ze Lee, Sara M. F. Turner, Kristi A. Streeter, David M. Baekey, and David D. Fuller. “Power spectral analysis of hypoglossal nerve activity during intermittent hypoxia-induced long-term facilitation in mice.J Neurophysiol 115, no. 3 (March 2016): 1372–80. https://doi.org/10.1152/jn.00479.2015.
ElMallah MK, Stanley DA, Lee K-Z, Turner SMF, Streeter KA, Baekey DM, et al. Power spectral analysis of hypoglossal nerve activity during intermittent hypoxia-induced long-term facilitation in mice. J Neurophysiol. 2016 Mar;115(3):1372–80.
ElMallah, Mai K., et al. “Power spectral analysis of hypoglossal nerve activity during intermittent hypoxia-induced long-term facilitation in mice.J Neurophysiol, vol. 115, no. 3, Mar. 2016, pp. 1372–80. Pubmed, doi:10.1152/jn.00479.2015.
ElMallah MK, Stanley DA, Lee K-Z, Turner SMF, Streeter KA, Baekey DM, Fuller DD. Power spectral analysis of hypoglossal nerve activity during intermittent hypoxia-induced long-term facilitation in mice. J Neurophysiol. 2016 Mar;115(3):1372–1380.

Published In

J Neurophysiol

DOI

EISSN

1522-1598

Publication Date

March 2016

Volume

115

Issue

3

Start / End Page

1372 / 1380

Location

United States

Related Subject Headings

  • Synaptic Potentials
  • Neurology & Neurosurgery
  • Mice
  • Male
  • Long-Term Potentiation
  • Hypoxia
  • Hypoglossal Nerve
  • Animals
  • 52 Psychology
  • 42 Health sciences