Smooth muscle cell signal transduction: implications of vascular biology for vascular surgeons.


Journal Article (Review)

Vascular smooth muscle cells exhibit varied responses after vessel injury and surgical interventions, including phenotypic switching, migration, proliferation, protein synthesis, and apoptosis. Although the source of the smooth muscle cells that accumulate in the vascular wall is controversial, possibly reflecting migration from the adventitia, from the circulating blood, or in situ differentiation, the intracellular signal transduction pathways that control these processes are being defined. Some of these pathways include the Ras-mitogen-activated protein kinase, phosphatidylinositol 3-kinase-Akt, Rho, death receptor-caspase, and nitric oxide pathways. Signal transduction pathways provide amplification, redundancy, and control points within the cell and culminate in biologic responses. We review some of the signaling pathways activated within smooth muscle cells that contribute to smooth muscle cell heterogeneity and development of pathology such as restenosis and neointimal hyperplasia.

Full Text

Cited Authors

  • Muto, A; Fitzgerald, TN; Pimiento, JM; Maloney, SP; Teso, D; Paszkowiak, JJ; Westvik, TS; Kudo, FA; Nishibe, T; Dardik, A

Published Date

  • June 2007

Published In

Volume / Issue

  • 45 Suppl A /

Start / End Page

  • A15 - A24

PubMed ID

  • 17544020

Pubmed Central ID

  • 17544020

Electronic International Standard Serial Number (EISSN)

  • 1097-6809

International Standard Serial Number (ISSN)

  • 0741-5214

Digital Object Identifier (DOI)

  • 10.1016/j.jvs.2007.02.061


  • eng