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What is the best ST-segment recovery parameter to predict clinical outcome and myocardial infarct size? Amplitude, speed, and completeness of ST-segment recovery after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction.

Publication ,  Journal Article
Kuijt, WJ; Green, CL; Verouden, NJW; Haeck, JDE; Tzivoni, D; Koch, KT; Stone, GW; Lansky, AJ; Broderick, S; Tijssen, JGP; de Winter, RJ ...
Published in: J Electrocardiol
2017

AIMS: ST-segment recovery (STR) is a strong mechanistic correlate of infarct size (IS) and outcome in ST-segment elevation myocardial infarction (STEMI). Characterizing measures of speed, amplitude, and completeness of STR may extend the use of this noninvasive biomarker. METHODS AND RESULTS: Core laboratory continuous 24-h 12-lead Holter ECG monitoring, IS by single-photon emission computed tomography (SPECT), and 30-day mortality of 2 clinical trials of primary percutaneous coronary intervention in STEMI were combined. Multiple ST measures (STR at last contrast injection (LC) measured from peak value; 30, 60, 90, 120, and 240min, residual deviation; time to steady ST recovery; and the 3-h area under the time trend curve [ST-AUC] from LC) were univariably correlated with IS and predictive of mortality. After multivariable adjustment for ST-parameters and GRACE risk factors, STR at 240min remained an additive predictor of mortality. Early STR, residual deviation, and ST-AUC remained associated with IS. CONCLUSIONS: Multiple parameters that quantify the speed, amplitude, and completeness of STR predict mortality and correlate with IS.

Duke Scholars

Published In

J Electrocardiol

DOI

EISSN

1532-8430

Publication Date

2017

Volume

50

Issue

6

Start / End Page

952 / 959

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Tomography, Emission-Computed, Single-Photon
  • ST Elevation Myocardial Infarction
  • Risk Factors
  • Predictive Value of Tests
  • Percutaneous Coronary Intervention
  • Middle Aged
  • Male
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kuijt, W. J., Green, C. L., Verouden, N. J. W., Haeck, J. D. E., Tzivoni, D., Koch, K. T., … Krucoff, M. W. (2017). What is the best ST-segment recovery parameter to predict clinical outcome and myocardial infarct size? Amplitude, speed, and completeness of ST-segment recovery after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. J Electrocardiol, 50(6), 952–959. https://doi.org/10.1016/j.jelectrocard.2017.04.009
Kuijt, Wichert J., Cindy L. Green, Niels J. W. Verouden, Joost D. E. Haeck, Dan Tzivoni, Karel T. Koch, Gregg W. Stone, et al. “What is the best ST-segment recovery parameter to predict clinical outcome and myocardial infarct size? Amplitude, speed, and completeness of ST-segment recovery after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction.J Electrocardiol 50, no. 6 (2017): 952–59. https://doi.org/10.1016/j.jelectrocard.2017.04.009.
Kuijt WJ, Green CL, Verouden NJW, Haeck JDE, Tzivoni D, Koch KT, Stone GW, Lansky AJ, Broderick S, Tijssen JGP, de Winter RJ, Roe MT, Krucoff MW. What is the best ST-segment recovery parameter to predict clinical outcome and myocardial infarct size? Amplitude, speed, and completeness of ST-segment recovery after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. J Electrocardiol. 2017;50(6):952–959.
Journal cover image

Published In

J Electrocardiol

DOI

EISSN

1532-8430

Publication Date

2017

Volume

50

Issue

6

Start / End Page

952 / 959

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Tomography, Emission-Computed, Single-Photon
  • ST Elevation Myocardial Infarction
  • Risk Factors
  • Predictive Value of Tests
  • Percutaneous Coronary Intervention
  • Middle Aged
  • Male
  • Humans
  • Female