Primary graft dysfunction after heart transplantation: Incidence, trends, and associated risk factors.

Published

Journal Article

Changes in heart transplantation (HT) donor and recipient demographics may influence the incidence of primary graft dysfunction (PGD). We conducted a retrospective study to evaluate PGD incidence, trends, and associated risk factors by analyzing consecutive adult patients who underwent HT between January 2009 and December 2014 at our institution. Patients were categorized as having PGD using the International Society for Heart & Lung Transplantation (ISHLT)-defined criteria. Variables, including clinical and demographic characteristics of donors and recipients, were selected to assess their independent association with PGD. A time-trend analysis was performed over the study period. Three-hundred seventeen patients met inclusion criteria. Left ventricular PGD, right ventricular PGD, or both, were observed in 99 patients (31%). Risk factors independently associated with PGD included ischemic time, recipient African American race, and recipient amiodarone treatment. Over the study period, there was no change in the PGD incidence; however, there was an increase in the recipient pretransplantation use of amiodarone. The rate of 30-day mortality was significantly elevated in those with PGD versus those without PGD (6.06% vs 0.92%, P = .01). Despite recent advancements, incidence of PGD remains high. Understanding associated risk factors may allow for implementation of targeted therapeutic interventions.

Full Text

Duke Authors

Cited Authors

  • Nicoara, A; Ruffin, D; Cooter, M; Patel, CB; Thompson, A; Schroder, JN; Daneshmand, MA; Hernandez, AF; Rogers, JG; Podgoreanu, MV; Swaminathan, M; Kretzer, A; Stafford-Smith, M; Milano, CA; Bartz, RR

Published Date

  • June 2018

Published In

Volume / Issue

  • 18 / 6

Start / End Page

  • 1461 - 1470

PubMed ID

  • 29136325

Pubmed Central ID

  • 29136325

Electronic International Standard Serial Number (EISSN)

  • 1600-6143

International Standard Serial Number (ISSN)

  • 1600-6135

Digital Object Identifier (DOI)

  • 10.1111/ajt.14588

Language

  • eng