Identification of new genetic variants of HLA-DQB1 associated with human longevity and lipid homeostasis-a cross-sectional study in a Chinese population.

Journal Article (Journal Article)

Healthy longevity has been an unremitting pursuit of human, but its genetic and the environment causes are still unclear. As longevity population is a good healthy aging model for understanding how the body begin aging and the process of aging, and plasma lipids metabolism and balance is a very important to life maintain and physiologic functional turnover. It is important to explore how the effect of genetic variants associated long-life individuals on lipids metabolism and balance. Therefore, we developed a comparative study based population which contains 2816 longevity and 2819 control. Through whole-exome sequencing and sanger sequencing genotypes, we identified four new single nucleotide polymorphisms of HLA-DQB1(major histocompatibility complex, class II, DQ beta 1), rs41542812 rs1049107 rs1049100 rs3891176(Prange=0.048-2.811×10-8 for allele frequencies), associated with longevity in Chinese Longevity Cohort. Further, by analysis of the longevity-variants linked to blood lipids, we identified HLA-DQB1 rs1049107, T-carriers (PHDL=0.006, OR: 11.277; PTG=9.095×10-7, OR: 0.025; PLDL/HDL=0.047, OR: 1.901) and HLA-DQB1 rs1049100, T-carriers (PTG=1.799×10-6, OR: 0.028) associated with lipid homeostasis in long lived individuals. Our finding showed that longevity and lipid homeostasis were associated with HLA-DQB1 and suggested that immune gene variants could act on both new function of maintaining the homeostasis and anti-aging in longevity.

Full Text

Duke Authors

Cited Authors

  • Yang, F; Sun, L; Zhu, X; Han, J; Zeng, Y; Nie, C; Yuan, H; Li, X; Shi, X; Yang, Y; Hu, C; Lv, Z; Huang, Z; Zheng, C; Liang, S; Huang, J; Wan, G; Qi, K; Qin, B; Cao, S; Zhao, X; Zhang, Y; Yang, Z

Published Date

  • November 10, 2017

Published In

Volume / Issue

  • 9 / 11

Start / End Page

  • 2316 - 2333

PubMed ID

  • 29129831

Pubmed Central ID

  • PMC5723689

Electronic International Standard Serial Number (EISSN)

  • 1945-4589

Digital Object Identifier (DOI)

  • 10.18632/aging.101323

Language

  • eng

Conference Location

  • United States