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Effectiveness of Florbetapir PET Imaging in Changing Patient Management.

Publication ,  Journal Article
Pontecorvo, MJ; Siderowf, A; Dubois, B; Doraiswamy, PM; Frisoni, GB; Grundman, M; Nobili, F; Sadowsky, CH; Salloway, S; Arora, AK; Chevrette, A ...
Published in: Dement Geriatr Cogn Disord
2017

AIMS: To evaluate the impact of amyloid PET imaging on diagnosis and patient management in a multicenter, randomized, controlled study. METHODS: Physicians identified patients seeking a diagnosis for mild cognitive impairment or dementia, possibly due to Alzheimer disease (AD), and recorded a working diagnosis and a management plan. The patients underwent florbetapir PET scanning and were randomized to either immediate or delayed (1-year) feedback regarding amyloid status. At the 3-month visit, the physician updated the diagnosis and recorded a summary of the actual patient management since the post-scan visit. The study examined the impact of immediate versus delayed feedback on patient diagnosis/management at 3 and 12 months. RESULTS: A total of 618 subjects were randomized (1:1) to immediate or delayed feedback arms, and 602 subjects completed the 3-month primary endpoint visit. A higher proportion of patients in the immediate feedback arm showed a change in diagnosis compared to the controls (32.6 vs. 6.4%; p = 0.0001). Similarly, a higher proportion of patients receiving immediate feedback had a change in management plan (68 vs. 55.5%; p < 0.002), mainly driven by changes in AD medication. Specifically, acetylcholinesterase inhibitors were prescribed to 67% of the amyloid-positive and 27% of the amyloid-negative subjects in the information group compared with 56 and 43%, respectively, in the control group (p < 0.0001). These between-group differences persisted until the 12-month visit. CONCLUSION: Knowledge of the amyloid status affects the diagnosis and alters patient management.

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Published In

Dement Geriatr Cogn Disord

DOI

EISSN

1421-9824

Publication Date

2017

Volume

44

Issue

3-4

Start / End Page

129 / 143

Location

Switzerland

Related Subject Headings

  • Prospective Studies
  • Positron-Emission Tomography
  • Plaque, Amyloid
  • Middle Aged
  • Male
  • Humans
  • Geriatrics
  • Follow-Up Studies
  • Female
  • Feedback
 

Citation

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Chicago
ICMJE
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Pontecorvo, M. J., Siderowf, A., Dubois, B., Doraiswamy, P. M., Frisoni, G. B., Grundman, M., … Mintun, M. A. (2017). Effectiveness of Florbetapir PET Imaging in Changing Patient Management. Dement Geriatr Cogn Disord, 44(3–4), 129–143. https://doi.org/10.1159/000478007
Pontecorvo, Michael J., Andrew Siderowf, Bruno Dubois, P Murali Doraiswamy, Giovanni B. Frisoni, Michael Grundman, Flavio Nobili, et al. “Effectiveness of Florbetapir PET Imaging in Changing Patient Management.Dement Geriatr Cogn Disord 44, no. 3–4 (2017): 129–43. https://doi.org/10.1159/000478007.
Pontecorvo MJ, Siderowf A, Dubois B, Doraiswamy PM, Frisoni GB, Grundman M, et al. Effectiveness of Florbetapir PET Imaging in Changing Patient Management. Dement Geriatr Cogn Disord. 2017;44(3–4):129–43.
Pontecorvo, Michael J., et al. “Effectiveness of Florbetapir PET Imaging in Changing Patient Management.Dement Geriatr Cogn Disord, vol. 44, no. 3–4, 2017, pp. 129–43. Pubmed, doi:10.1159/000478007.
Pontecorvo MJ, Siderowf A, Dubois B, Doraiswamy PM, Frisoni GB, Grundman M, Nobili F, Sadowsky CH, Salloway S, Arora AK, Chevrette A, Deberdt W, Dell’Agnello G, Flitter M, Galante N, Lowrey MJ, Lu M, McGeehan A, Devous MD, Mintun MA. Effectiveness of Florbetapir PET Imaging in Changing Patient Management. Dement Geriatr Cogn Disord. 2017;44(3–4):129–143.
Journal cover image

Published In

Dement Geriatr Cogn Disord

DOI

EISSN

1421-9824

Publication Date

2017

Volume

44

Issue

3-4

Start / End Page

129 / 143

Location

Switzerland

Related Subject Headings

  • Prospective Studies
  • Positron-Emission Tomography
  • Plaque, Amyloid
  • Middle Aged
  • Male
  • Humans
  • Geriatrics
  • Follow-Up Studies
  • Female
  • Feedback