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Polyclonal polymorphic B-cell lymphoproliferative disorder with prominent pulmonary involvement in children with acquired immune deficiency syndrome.

Publication ,  Journal Article
Joshi, VV; Kauffman, S; Oleske, JM; Fikrig, S; Denny, T; Gadol, C; Lee, E
Published in: Cancer
April 15, 1987

Four cases of pediatric Acquired Immune Deficiency Syndrome (AIDS) with lymphoproliferative disorder are described and other lymphoid lesions in previously reported cases of pediatric AIDS are reviewed. The lymphoproliferative disorder was characterized by polyclonal, polymorphic B-cell content without evidence of cellular atypia, necrosis or prominent mitotic activity but with predominantly extranodal systemic and prominent pulmonary involvement. Since the lesion has overlapping features it is considered to be intermediate between benign and malignant lymphoproliferations and designated as polyclonal, polymorphic B-cell lymphoproliferative disorder (PBLD) of pediatric AIDS. The PBLD is part of a spectrum of lymphoid lesions in pediatric AIDS consisting of follicular lymphoid hyperplasia of nodal and extranodal sites, pulmonary lymphoid hyperplasia/lymphoid interstitial pneumonitis complex (PLH/LIP complex) in cases previously reported by the authors, and also malignant lymphoma reported by others. It is possible that Epstein-Barr virus (EBV) by itself or in synergism with human T-lymphotropic virus-type III (HTLV-III) is related to pathogenesis of PBLD in children with AIDS.

Duke Scholars

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

April 15, 1987

Volume

59

Issue

8

Start / End Page

1455 / 1462

Location

United States

Related Subject Headings

  • Thymus Gland
  • Pulmonary Fibrosis
  • Oncology & Carcinogenesis
  • Male
  • Lymphoproliferative Disorders
  • Lymph Nodes
  • Lung
  • Infant
  • Hyperplasia
  • Humans
 

Citation

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Joshi, V. V., Kauffman, S., Oleske, J. M., Fikrig, S., Denny, T., Gadol, C., & Lee, E. (1987). Polyclonal polymorphic B-cell lymphoproliferative disorder with prominent pulmonary involvement in children with acquired immune deficiency syndrome. Cancer, 59(8), 1455–1462. https://doi.org/10.1002/1097-0142(19870415)59:8<1455::aid-cncr2820590811>3.0.co;2-d
Joshi, V. V., S. Kauffman, J. M. Oleske, S. Fikrig, T. Denny, C. Gadol, and E. Lee. “Polyclonal polymorphic B-cell lymphoproliferative disorder with prominent pulmonary involvement in children with acquired immune deficiency syndrome.Cancer 59, no. 8 (April 15, 1987): 1455–62. https://doi.org/10.1002/1097-0142(19870415)59:8<1455::aid-cncr2820590811>3.0.co;2-d.
Joshi VV, Kauffman S, Oleske JM, Fikrig S, Denny T, Gadol C, et al. Polyclonal polymorphic B-cell lymphoproliferative disorder with prominent pulmonary involvement in children with acquired immune deficiency syndrome. Cancer. 1987 Apr 15;59(8):1455–62.
Joshi, V. V., et al. “Polyclonal polymorphic B-cell lymphoproliferative disorder with prominent pulmonary involvement in children with acquired immune deficiency syndrome.Cancer, vol. 59, no. 8, Apr. 1987, pp. 1455–62. Pubmed, doi:10.1002/1097-0142(19870415)59:8<1455::aid-cncr2820590811>3.0.co;2-d.
Joshi VV, Kauffman S, Oleske JM, Fikrig S, Denny T, Gadol C, Lee E. Polyclonal polymorphic B-cell lymphoproliferative disorder with prominent pulmonary involvement in children with acquired immune deficiency syndrome. Cancer. 1987 Apr 15;59(8):1455–1462.
Journal cover image

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

April 15, 1987

Volume

59

Issue

8

Start / End Page

1455 / 1462

Location

United States

Related Subject Headings

  • Thymus Gland
  • Pulmonary Fibrosis
  • Oncology & Carcinogenesis
  • Male
  • Lymphoproliferative Disorders
  • Lymph Nodes
  • Lung
  • Infant
  • Hyperplasia
  • Humans