Using Retinal Imaging to Study Dementia.

Journal Article (Journal Article)

The retina offers a unique "window" to study pathophysiological processes of dementia in the brain, as it is an extension of the central nervous system (CNS) and shares prominent similarities with the brain in terms of embryological origin, anatomical features and physiological properties.  The vascular and neuronal structure in the retina can now be visualized easily and non-invasively using retinal imaging techniques, including fundus photography and optical coherence tomography (OCT), and quantified semi-automatically using computer-assisted analysis programs. Studying the associations between vascular and neuronal changes in the retina and dementia could improve our understanding of dementia and, potentially, aid in diagnosis and risk assessment.  This protocol aims to describe a method of quantifying and analyzing retinal vasculature and neuronal structure, which are potentially associated with dementia. This protocol also provides examples of retinal changes in subjects with dementia, and discusses technical issues and current limitations of retinal imaging.

Full Text

Duke Authors

Cited Authors

  • Chan, VTT; Tso, THK; Tang, F; Tham, C; Mok, V; Chen, C; Wong, TY; Cheung, CY

Published Date

  • November 6, 2017

Published In

PubMed ID

  • 29155753

Pubmed Central ID

  • PMC5755325

Electronic International Standard Serial Number (EISSN)

  • 1940-087X

Digital Object Identifier (DOI)

  • 10.3791/56137


  • eng

Conference Location

  • United States