Thromboembolism after WATCHMANTM in a clopidogrel non-responder: A case for concern?
Journal Article
Atrial fibrillation (AF) is associated with an increased risk of stroke and thromboembolism (TE). The WATCHMANTM left atrial appendage (LAA) closure device is indicated to reduce the risk of TE from the LAA in patients with non-valvular AF. Here, we present a case of a patient with device-related thrombus who suffered a TE event two months after WATCHMANTM LAA closure and two weeks after switching from aspirin plus warfarin to aspirin plus clopidogrel therapy. Laboratory investigation identified the patient to be hypercoagulable and to be a non-responder to clopidogrel therapy. We discuss the potential role of platelet function testing to prevent device-related thrombi.
Full Text
Duke Authors
Cited Authors
- Venkataraman, G; Bliden, KP; Tantry, US; Gurbel, PA
Published Date
- July 2018
Published In
Volume / Issue
- 92 / 1
Start / End Page
- 200 - 202
PubMed ID
- 29130638
Electronic International Standard Serial Number (EISSN)
- 1522-726X
Digital Object Identifier (DOI)
- 10.1002/ccd.27402
Language
- eng
Conference Location
- United States