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Associations of Circulating Growth Differentiation Factor-15 and ST2 Concentrations With Subclinical Vascular Brain Injury and Incident Stroke.

Publication ,  Journal Article
Andersson, C; Preis, SR; Beiser, A; DeCarli, C; Wollert, KC; Wang, TJ; Januzzi, JL; Vasan, RS; Seshadri, S
Published in: Stroke
September 2015

BACKGROUND AND PURPOSE: Growth differentiation factor-15 (GDF-15) and soluble (s)ST2 are markers of cardiac and vascular stress. We investigated the associations between circulating concentrations of these biomarkers and incident stroke and subclinical vascular brain injury in a sample from the Framingham Offspring cohort. METHODS: We followed 3374 stroke- and dementia-free individuals (mean age, 59.0±9.7 years; 53% women) attending the Framingham Offspring sixth examination cycle 11.8±3.0 years for incident stroke. A subsample of 2463 individuals underwent brain magnetic resonance imaging and neuropsychological testing ≈4.0±1.7 years after the sixth examination. RESULTS: After adjustment for traditional cardiovascular risk factors, B-type natriuretic peptide, high-sensitivity C-reactive protein, and urine albumin levels, higher stress biomarker levels were associated cross-sectionally with lower brain volumes (β coefficients for intracranial volume comparing fourth [Q4] versus first biomarker [Q1] quartiles: -0.71% for GDF-15; P=0.002 and 0.47% for sST2; P=0.02) and worse performance on the visual reproduction test (β coefficients for Q4 versus Q1: -0.62 for GDF-15; P=0.009 and -0.40 for sST2; P=0.04). Higher GDF-15 concentrations were also associated with greater log-transformed white-matter hyperintensity volumes (β for Q4 versus Q1=0.19; P=0.01). Prospectively, a total of 203 (6%) individuals developed incident stroke/transient ischemic attack during follow-up. After multivariable adjustment, sST2 remained significantly associated with stroke/transient ischemic attack, hazard ratio for Q4 versus Q1 of 1.76, 95% confidence interval of 1.06 to 2.92, and P=0.03. CONCLUSIONS: Circulating GDF-15 and sST2 are associated with subclinical brain injury and cognitive impairment. Higher sST2 concentrations are also associated with incident stroke, suggesting potential links between cardiac stress biomarkers and brain injury.

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Published In

Stroke

DOI

EISSN

1524-4628

Publication Date

September 2015

Volume

46

Issue

9

Start / End Page

2568 / 2575

Location

United States

Related Subject Headings

  • Stroke
  • Receptors, Cell Surface
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Longitudinal Studies
  • Ischemic Attack, Transient
  • Interleukin-1 Receptor-Like 1 Protein
  • Humans
 

Citation

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Andersson, C., Preis, S. R., Beiser, A., DeCarli, C., Wollert, K. C., Wang, T. J., … Seshadri, S. (2015). Associations of Circulating Growth Differentiation Factor-15 and ST2 Concentrations With Subclinical Vascular Brain Injury and Incident Stroke. Stroke, 46(9), 2568–2575. https://doi.org/10.1161/STROKEAHA.115.009026
Andersson, Charlotte, Sarah R. Preis, Alexa Beiser, Charles DeCarli, Kai C. Wollert, Thomas J. Wang, James L. Januzzi, Ramachandran S. Vasan, and Sudha Seshadri. “Associations of Circulating Growth Differentiation Factor-15 and ST2 Concentrations With Subclinical Vascular Brain Injury and Incident Stroke.Stroke 46, no. 9 (September 2015): 2568–75. https://doi.org/10.1161/STROKEAHA.115.009026.
Andersson C, Preis SR, Beiser A, DeCarli C, Wollert KC, Wang TJ, et al. Associations of Circulating Growth Differentiation Factor-15 and ST2 Concentrations With Subclinical Vascular Brain Injury and Incident Stroke. Stroke. 2015 Sep;46(9):2568–75.
Andersson, Charlotte, et al. “Associations of Circulating Growth Differentiation Factor-15 and ST2 Concentrations With Subclinical Vascular Brain Injury and Incident Stroke.Stroke, vol. 46, no. 9, Sept. 2015, pp. 2568–75. Pubmed, doi:10.1161/STROKEAHA.115.009026.
Andersson C, Preis SR, Beiser A, DeCarli C, Wollert KC, Wang TJ, Januzzi JL, Vasan RS, Seshadri S. Associations of Circulating Growth Differentiation Factor-15 and ST2 Concentrations With Subclinical Vascular Brain Injury and Incident Stroke. Stroke. 2015 Sep;46(9):2568–2575.

Published In

Stroke

DOI

EISSN

1524-4628

Publication Date

September 2015

Volume

46

Issue

9

Start / End Page

2568 / 2575

Location

United States

Related Subject Headings

  • Stroke
  • Receptors, Cell Surface
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Longitudinal Studies
  • Ischemic Attack, Transient
  • Interleukin-1 Receptor-Like 1 Protein
  • Humans