The relationship between symptoms and IgG and IgE antibodies in an office environment.


Journal Article

Airborne fungi have been postulated as a cause of symptoms among office workers. Using the MAST chemiluminescent system, this study evaluated 36 IgG and 36 IgE antibody levels in 47 office workers from an area with elevated airborne fungal concentrations and 44 office workers from an otherwise similar area with lower airborne fungal exposure. No difference was found in IgG antibody to fungi between the lower and higher exposure areas, but high IgG antibody to one or more of the fungi studied was detected in 67% of all the workers tested. IgE antibody to one or more antigens was detected in 40% of the participants. Workers who reported atopic symptoms (sneezing, runny nose, and itchy eyes) or "sick building" symptoms (any three of the following temporally related to work: headache, fatigue, stuffy nose, irritated eyes, or sore throat) were more likely to have one positive IgE antibody test. Type I hypersensitivity to aeroallergens besides fungi may play a role in some symptoms reported by some participants in this office building.

Full Text

Duke Authors

Cited Authors

  • Malkin, R; Martinez, K; Marinkovich, V; Wilcox, T; Wall, D; Biagini, R

Published Date

  • February 1998

Published In

Volume / Issue

  • 76 / 2

Start / End Page

  • 85 - 93

PubMed ID

  • 9515063

Pubmed Central ID

  • 9515063

Electronic International Standard Serial Number (EISSN)

  • 1096-0953

International Standard Serial Number (ISSN)

  • 0013-9351

Digital Object Identifier (DOI)

  • 10.1006/enrs.1997.3800


  • eng