A novel role for renal epithelial cells and the medullary sodium gradient in the local immune response.

Journal Article (Journal Article)

The extreme hypertonicity of the renal medulla plays a central role in regulating volume status. A recent publication in Cell has identified a novel role for the high sodium environment and the local epithelial cells in the recruitment of mononuclear phagocytes, potentially contributing to the defense against ascending urinary tract infection.

Full Text

Duke Authors

Cited Authors

  • Wyatt, CM; Crowley, SD

Published Date

  • December 2017

Published In

Volume / Issue

  • 92 / 6

Start / End Page

  • 1308 - 1311

PubMed ID

  • 29153132

Electronic International Standard Serial Number (EISSN)

  • 1523-1755

Digital Object Identifier (DOI)

  • 10.1016/j.kint.2017.10.005


  • eng

Conference Location

  • United States