Salt, Hypertension, and Immunity.

Journal Article (Journal Article;Review)

The link between inappropriate salt retention in the kidney and hypertension is well recognized. However, growing evidence suggests that the immune system can play surprising roles in sodium homeostasis, such that the study of inflammatory cells and their secreted effectors has provided important insights into salt sensitivity. As part of the innate immune system, myeloid cells have diverse roles in blood pressure regulation, ranging from prohypertensive actions in the kidney, vasculature, and brain, to effects in the skin that attenuate blood pressure elevation. In parallel, T lymphocyte subsets, as key constituents of the adaptive immune compartment, have variable effects on renal sodium handling and the hypertensive response, accruing from the functions of the cytokines that they produce. Conversely, salt can directly modulate the phenotypes of myeloid and T cells, illustrating bidirectional regulatory mechanisms through which sodium and the immune system coordinately impact blood pressure. This review details the complex interplay between myeloid cells, T cells, and salt in the pathogenesis of essential hypertension.

Full Text

Duke Authors

Cited Authors

  • Rucker, AJ; Rudemiller, NP; Crowley, SD

Published Date

  • February 10, 2018

Published In

Volume / Issue

  • 80 /

Start / End Page

  • 283 - 307

PubMed ID

  • 29144825

Pubmed Central ID

  • PMC5811318

Electronic International Standard Serial Number (EISSN)

  • 1545-1585

Digital Object Identifier (DOI)

  • 10.1146/annurev-physiol-021317-121134


  • eng

Conference Location

  • United States