The Broader Autism Phenotype in Mothers is Associated with Increased Discordance Between Maternal-Reported and Clinician-Observed Instruments that Measure Child Autism Spectrum Disorder.

Published

Journal Article

Autism spectrum disorder (ASD) diagnosis relies on parent-reported and clinician-observed instruments. Sometimes, results between these instruments disagree. The broader autism phenotype (BAP) in parent-reporters may be associated with discordance. Study to Explore Early Development data (N = 712) were used to address whether mothers with BAP and children with ASD or non-ASD developmental disabilities were more likely than mothers without BAP to 'over-' or 'under-report' child ASD on ASD screeners or interviews compared with clinician observation or overall impression. Maternal BAP was associated with a child meeting thresholds on a maternal-reported screener or maternal interview when clinician ASD instruments or impressions did not (risk ratios: 1.30 to 2.85). Evidence suggests acknowledging and accounting for reporting discordances may be important when diagnosing ASD.

Full Text

Duke Authors

Cited Authors

  • Rubenstein, E; Edmondson Pretzel, R; Windham, GC; Schieve, LA; Wiggins, LD; DiGuiseppi, C; Olshan, AF; Howard, AG; Pence, BW; Young, L; Daniels, J

Published Date

  • October 2017

Published In

Volume / Issue

  • 47 / 10

Start / End Page

  • 3253 - 3266

PubMed ID

  • 28748335

Pubmed Central ID

  • 28748335

Electronic International Standard Serial Number (EISSN)

  • 1573-3432

Digital Object Identifier (DOI)

  • 10.1007/s10803-017-3248-4

Language

  • eng

Conference Location

  • United States