Nasal dry powder vaccine delivery technology


Book Section

© Springer International Publishing Switzerland 2014. All rights reserved. Nasal delivery of vaccines occurred over a millennium ago in China, where ground scabs from small pox lesions, presumably containing live virus, were sniffed. This practice was the basis for early vaccination with live virus in Europe in the eighteenth century. In the past decade, a number of reports have focused on new antigens, adjuvants, and delivery systems, but few approaches have entered development as a clinical candidate. This chapter outlines the critical steps needed to create a comprehensive integrated strategy adopting an antigen, with candidate physical and biochemical adjuvants, in a delivery system. There is a need to define unique formulation and device performance properties, evaluate dose sparing achieved through novel construction and adjuvancy, and develop rapid screening methods to identify toxic formulations.

Full Text

Duke Authors

Cited Authors

  • Hickey, AJ; Staats, H; Roy, CJ; Powell, KG; Sullivan, V; Rothrock, G; Sayes, CM

Published Date

  • January 1, 2014

Book Title

  • Molecular Vaccines: From Prophylaxis to Therapy - Volume 2

Start / End Page

  • 717 - 726

International Standard Book Number 13 (ISBN-13)

  • 9783319009773

Digital Object Identifier (DOI)

  • 10.1007/978-3-319-00978-0_18

Citation Source

  • Scopus