A novel and efficient method for the preparation of asymmetric dithioacetals

Journal Article (Journal Article)

Aldehydes and ketones react with one equivalent each of thiols and thiolacetic acid under acid catalysis to yield almost exclusively the mixed alkylthio-(or arylthio-) acylthioacetals. Reaction of the mixed thioacetal with a nucleophile (such as NaOMe) liberates the thiolate anion which can be trapped with a variety of electrophiles to provide asymmetric dithioacetals in high yields. © 1988.

Full Text

Duke Authors

Cited Authors

  • Gauthier, JY; Henien, T; Lo, L; Thérien, M; Young, RN

Published Date

  • January 1, 1988

Published In

Volume / Issue

  • 29 / 51

Start / End Page

  • 6729 - 6732

International Standard Serial Number (ISSN)

  • 0040-4039

Digital Object Identifier (DOI)

  • 10.1016/S0040-4039(00)82440-5

Citation Source

  • Scopus