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Synthesis and biological evaluation of 5,6-diarylimidazo[2.1-b]thiazole as selective COX-2 inhibitors

Publication ,  Journal Article
Thérien, M; Brideau, C; Chan, CC; Cromlish, WA; Gauthier, JY; Gordon, R; Greig, G; Kargman, S; Lau, CK; Leblanc, Y; Li, CS; O'Neill, GP ...
Published in: Bioorganic and Medicinal Chemistry Letters
January 7, 1997

A series of 5,6-diarylimidazo[2.1-b]thiazole compounds were prepared and their inhibitory potencies against COX-2 and Cox-1 enzymes were measured. This led to the identification of L-766,112 as a potent, orally active and selective inhibitor of the COX-2 enzyme.

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Published In

Bioorganic and Medicinal Chemistry Letters

DOI

ISSN

0960-894X

Publication Date

January 7, 1997

Volume

7

Issue

1

Start / End Page

47 / 52

Related Subject Headings

  • Medicinal & Biomolecular Chemistry
  • 3405 Organic chemistry
  • 3404 Medicinal and biomolecular chemistry
  • 1115 Pharmacology and Pharmaceutical Sciences
  • 0305 Organic Chemistry
  • 0304 Medicinal and Biomolecular Chemistry
 

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Thérien, M., Brideau, C., Chan, C. C., Cromlish, W. A., Gauthier, J. Y., Gordon, R., … Prasit, P. (1997). Synthesis and biological evaluation of 5,6-diarylimidazo[2.1-b]thiazole as selective COX-2 inhibitors. Bioorganic and Medicinal Chemistry Letters, 7(1), 47–52. https://doi.org/10.1016/S0960-894X(96)00580-X
Thérien, M., C. Brideau, C. C. Chan, W. A. Cromlish, J. Y. Gauthier, R. Gordon, G. Greig, et al. “Synthesis and biological evaluation of 5,6-diarylimidazo[2.1-b]thiazole as selective COX-2 inhibitors.” Bioorganic and Medicinal Chemistry Letters 7, no. 1 (January 7, 1997): 47–52. https://doi.org/10.1016/S0960-894X(96)00580-X.
Thérien M, Brideau C, Chan CC, Cromlish WA, Gauthier JY, Gordon R, et al. Synthesis and biological evaluation of 5,6-diarylimidazo[2.1-b]thiazole as selective COX-2 inhibitors. Bioorganic and Medicinal Chemistry Letters. 1997 Jan 7;7(1):47–52.
Thérien, M., et al. “Synthesis and biological evaluation of 5,6-diarylimidazo[2.1-b]thiazole as selective COX-2 inhibitors.” Bioorganic and Medicinal Chemistry Letters, vol. 7, no. 1, Jan. 1997, pp. 47–52. Scopus, doi:10.1016/S0960-894X(96)00580-X.
Thérien M, Brideau C, Chan CC, Cromlish WA, Gauthier JY, Gordon R, Greig G, Kargman S, Lau CK, Leblanc Y, Li CS, O’Neill GP, Riendeau D, Roy P, Wang Z, Xu L, Prasit P. Synthesis and biological evaluation of 5,6-diarylimidazo[2.1-b]thiazole as selective COX-2 inhibitors. Bioorganic and Medicinal Chemistry Letters. 1997 Jan 7;7(1):47–52.
Journal cover image

Published In

Bioorganic and Medicinal Chemistry Letters

DOI

ISSN

0960-894X

Publication Date

January 7, 1997

Volume

7

Issue

1

Start / End Page

47 / 52

Related Subject Headings

  • Medicinal & Biomolecular Chemistry
  • 3405 Organic chemistry
  • 3404 Medicinal and biomolecular chemistry
  • 1115 Pharmacology and Pharmaceutical Sciences
  • 0305 Organic Chemistry
  • 0304 Medicinal and Biomolecular Chemistry