Synthesis and biological evaluation of 5,6-diarylimidazo[2.1-b]thiazole as selective COX-2 inhibitors
Journal Article (Journal Article)
A series of 5,6-diarylimidazo[2.1-b]thiazole compounds were prepared and their inhibitory potencies against COX-2 and Cox-1 enzymes were measured. This led to the identification of L-766,112 as a potent, orally active and selective inhibitor of the COX-2 enzyme.
Full Text
Duke Authors
Cited Authors
- Thérien, M; Brideau, C; Chan, CC; Cromlish, WA; Gauthier, JY; Gordon, R; Greig, G; Kargman, S; Lau, CK; Leblanc, Y; Li, CS; O'Neill, GP; Riendeau, D; Roy, P; Wang, Z; Xu, L; Prasit, P
Published Date
- January 7, 1997
Published In
Volume / Issue
- 7 / 1
Start / End Page
- 47 - 52
International Standard Serial Number (ISSN)
- 0960-894X
Digital Object Identifier (DOI)
- 10.1016/S0960-894X(96)00580-X
Citation Source
- Scopus