Synthesis and biological evaluation of 5,6-diarylimidazo[2.1-b]thiazole as selective COX-2 inhibitors

Journal Article (Journal Article)

A series of 5,6-diarylimidazo[2.1-b]thiazole compounds were prepared and their inhibitory potencies against COX-2 and Cox-1 enzymes were measured. This led to the identification of L-766,112 as a potent, orally active and selective inhibitor of the COX-2 enzyme.

Full Text

Duke Authors

Cited Authors

  • Thérien, M; Brideau, C; Chan, CC; Cromlish, WA; Gauthier, JY; Gordon, R; Greig, G; Kargman, S; Lau, CK; Leblanc, Y; Li, CS; O'Neill, GP; Riendeau, D; Roy, P; Wang, Z; Xu, L; Prasit, P

Published Date

  • January 7, 1997

Published In

Volume / Issue

  • 7 / 1

Start / End Page

  • 47 - 52

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/S0960-894X(96)00580-X

Citation Source

  • Scopus