Pyridazinones as selective cyclooxygenase-2 inhibitors.

Journal Article (Journal Article)

Pyridazinone was found to be an excellent core template for selective COX-2 inhibitors. Two potent, selective and orally active COX-2 inhibitors, which were highly efficacious in rat paw edema and rat pyresis models, have been obtained.

Full Text

Duke Authors

Cited Authors

  • Li, CS; Brideau, C; Chan, CC; Savoie, C; Claveau, D; Charleson, S; Gordon, R; Greig, G; Gauthier, JY; Lau, CK; Riendeau, D; Thérien, M; Wong, E; Prasit, P

Published Date

  • February 2003

Published In

Volume / Issue

  • 13 / 4

Start / End Page

  • 597 - 600

PubMed ID

  • 12639538

Electronic International Standard Serial Number (EISSN)

  • 1464-3405

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/s0960-894x(02)01045-4


  • eng