Pyridazinones as selective cyclooxygenase-2 inhibitors.
Journal Article (Journal Article)
Pyridazinone was found to be an excellent core template for selective COX-2 inhibitors. Two potent, selective and orally active COX-2 inhibitors, which were highly efficacious in rat paw edema and rat pyresis models, have been obtained.
Full Text
Duke Authors
Cited Authors
- Li, CS; Brideau, C; Chan, CC; Savoie, C; Claveau, D; Charleson, S; Gordon, R; Greig, G; Gauthier, JY; Lau, CK; Riendeau, D; Thérien, M; Wong, E; Prasit, P
Published Date
- February 2003
Published In
Volume / Issue
- 13 / 4
Start / End Page
- 597 - 600
PubMed ID
- 12639538
Electronic International Standard Serial Number (EISSN)
- 1464-3405
International Standard Serial Number (ISSN)
- 0960-894X
Digital Object Identifier (DOI)
- 10.1016/s0960-894x(02)01045-4
Language
- eng