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A new series of selective COX-2 inhibitors: 5,6-diarylthiazolo[3,2-b][1,2,4]triazoles

Publication ,  Journal Article
Roy, P; Leblanc, Y; Ball, RG; Brideau, C; Chan, CC; Chauret, N; Cromlish, W; Ethier, D; Gauthier, JY; Gordon, R; Greig, G; Guay, J; Lau, CK ...
Published in: Bioorganic and Medicinal Chemistry Letters
January 7, 1997

A series of 5,6-diarylthiazolo[3,2-b][1,2,4]triazoles was prepared for evaluation of potency and selectivity against human COX-1 and COX-2 enzymes. This lead to the discovery of L-768,277, a potent and selective COX-2 inhibitor that also demonstrated good in vivo activity.

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Published In

Bioorganic and Medicinal Chemistry Letters

DOI

ISSN

0960-894X

Publication Date

January 7, 1997

Volume

7

Issue

1

Start / End Page

57 / 62

Related Subject Headings

  • Medicinal & Biomolecular Chemistry
  • 3405 Organic chemistry
  • 3404 Medicinal and biomolecular chemistry
  • 1115 Pharmacology and Pharmaceutical Sciences
  • 0305 Organic Chemistry
  • 0304 Medicinal and Biomolecular Chemistry
 

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Roy, P., Leblanc, Y., Ball, R. G., Brideau, C., Chan, C. C., Chauret, N., … Prasit, P. (1997). A new series of selective COX-2 inhibitors: 5,6-diarylthiazolo[3,2-b][1,2,4]triazoles. Bioorganic and Medicinal Chemistry Letters, 7(1), 57–62. https://doi.org/10.1016/S0960-894X(96)00582-3
Roy, P., Y. Leblanc, R. G. Ball, C. Brideau, C. C. Chan, N. Chauret, W. Cromlish, et al. “A new series of selective COX-2 inhibitors: 5,6-diarylthiazolo[3,2-b][1,2,4]triazoles.” Bioorganic and Medicinal Chemistry Letters 7, no. 1 (January 7, 1997): 57–62. https://doi.org/10.1016/S0960-894X(96)00582-3.
Roy P, Leblanc Y, Ball RG, Brideau C, Chan CC, Chauret N, et al. A new series of selective COX-2 inhibitors: 5,6-diarylthiazolo[3,2-b][1,2,4]triazoles. Bioorganic and Medicinal Chemistry Letters. 1997 Jan 7;7(1):57–62.
Roy, P., et al. “A new series of selective COX-2 inhibitors: 5,6-diarylthiazolo[3,2-b][1,2,4]triazoles.” Bioorganic and Medicinal Chemistry Letters, vol. 7, no. 1, Jan. 1997, pp. 57–62. Scopus, doi:10.1016/S0960-894X(96)00582-3.
Roy P, Leblanc Y, Ball RG, Brideau C, Chan CC, Chauret N, Cromlish W, Ethier D, Gauthier JY, Gordon R, Greig G, Guay J, Kargman S, Lau CK, O’Neill G, Silva J, Thérien M, Van Staden C, Wong E, Xu L, Prasit P. A new series of selective COX-2 inhibitors: 5,6-diarylthiazolo[3,2-b][1,2,4]triazoles. Bioorganic and Medicinal Chemistry Letters. 1997 Jan 7;7(1):57–62.
Journal cover image

Published In

Bioorganic and Medicinal Chemistry Letters

DOI

ISSN

0960-894X

Publication Date

January 7, 1997

Volume

7

Issue

1

Start / End Page

57 / 62

Related Subject Headings

  • Medicinal & Biomolecular Chemistry
  • 3405 Organic chemistry
  • 3404 Medicinal and biomolecular chemistry
  • 1115 Pharmacology and Pharmaceutical Sciences
  • 0305 Organic Chemistry
  • 0304 Medicinal and Biomolecular Chemistry