A new series of selective COX-2 inhibitors: 5,6-diarylthiazolo[3,2-b][1,2,4]triazoles

Journal Article (Journal Article)

A series of 5,6-diarylthiazolo[3,2-b][1,2,4]triazoles was prepared for evaluation of potency and selectivity against human COX-1 and COX-2 enzymes. This lead to the discovery of L-768,277, a potent and selective COX-2 inhibitor that also demonstrated good in vivo activity.

Full Text

Duke Authors

Cited Authors

  • Roy, P; Leblanc, Y; Ball, RG; Brideau, C; Chan, CC; Chauret, N; Cromlish, W; Ethier, D; Gauthier, JY; Gordon, R; Greig, G; Guay, J; Kargman, S; Lau, CK; O'Neill, G; Silva, J; Thérien, M; Van Staden, C; Wong, E; Xu, L; Prasit, P

Published Date

  • January 7, 1997

Published In

Volume / Issue

  • 7 / 1

Start / End Page

  • 57 - 62

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/S0960-894X(96)00582-3

Citation Source

  • Scopus