Scanning system for angle-resolved low-coherence interferometry.

Journal Article (Journal Article)

Angle-resolved low-coherence interferometry (a/LCI) detects precancer by enabling depth-resolved measurements of nuclear morphology in vivo. A significant limitation of a/LCI is the point-probe nature of the method, sampling <0.5  mm2 before probe relocation is necessary. In this work, we demonstrate a scanning method capable of assessing an area >100  mm2 without repositioning. By utilizing a reflection-only three-optic rotator prism and a two-axis scanning mirror, we demonstrate radial scans of a sample with a linear range of 12 mm and a full rotational range of 180°. Use of this design will improve the diagnostic utility of a/LCI for wide-area screening of tissue health.

Full Text

Duke Authors

Cited Authors

  • Steelman, ZA; Ho, D; Chu, KK; Wax, A

Published Date

  • November 2017

Published In

Volume / Issue

  • 42 / 22

Start / End Page

  • 4581 - 4584

PubMed ID

  • 29140317

Pubmed Central ID

  • PMC5777518

Electronic International Standard Serial Number (EISSN)

  • 1539-4794

International Standard Serial Number (ISSN)

  • 0146-9592

Digital Object Identifier (DOI)

  • 10.1364/ol.42.004581


  • eng