Scanning system for angle-resolved low-coherence interferometry.
Journal Article (Journal Article)
Angle-resolved low-coherence interferometry (a/LCI) detects precancer by enabling depth-resolved measurements of nuclear morphology in vivo. A significant limitation of a/LCI is the point-probe nature of the method, sampling <0.5 mm2 before probe relocation is necessary. In this work, we demonstrate a scanning method capable of assessing an area >100 mm2 without repositioning. By utilizing a reflection-only three-optic rotator prism and a two-axis scanning mirror, we demonstrate radial scans of a sample with a linear range of 12 mm and a full rotational range of 180°. Use of this design will improve the diagnostic utility of a/LCI for wide-area screening of tissue health.
Full Text
Duke Authors
Cited Authors
- Steelman, ZA; Ho, D; Chu, KK; Wax, A
Published Date
- November 2017
Published In
Volume / Issue
- 42 / 22
Start / End Page
- 4581 - 4584
PubMed ID
- 29140317
Pubmed Central ID
- PMC5777518
Electronic International Standard Serial Number (EISSN)
- 1539-4794
International Standard Serial Number (ISSN)
- 0146-9592
Digital Object Identifier (DOI)
- 10.1364/ol.42.004581
Language
- eng