Redox therapy in neonatal sepsis: reasons, targets, strategy, and agents.


Journal Article (Review)

Neonatal sepsis is one of the most fulminating conditions in neonatal intensive care units. Antipathogen and supportive care are administered routinely, but do not deliver satisfactory results. In addition, the efforts to treat neonatal sepsis with anti-inflammatory agents have generally shown to be futile. The accumulating data imply that intracellular redox changes intertwined into neonatal sepsis redox cycle represent the main cause of dysfunction of mitochondria and cells in neonatal sepsis. Our aim here is to support the new philosophy in neonatal sepsis treatment, which involves the integration of mechanisms that are responsible for cellular dysfunction and organ failure, the recognition of the most important targets, and the selection of safe agents that can stop the neonatal sepsis redox cycle by hitting the hot spots. Redox-active agents that could be beneficial for neonatal sepsis treatment according to these criteria include lactoferrin, interleukin 10, zinc and selenium supplements, ibuprofen, edaravone, and pentoxifylline.

Full Text

Cited Authors

  • Bajčetić, M; Spasić, S; Spasojević, I

Published Date

  • September 2014

Published In

Volume / Issue

  • 42 / 3

Start / End Page

  • 179 - 184

PubMed ID

  • 24827393

Pubmed Central ID

  • 24827393

Electronic International Standard Serial Number (EISSN)

  • 1540-0514

International Standard Serial Number (ISSN)

  • 1073-2322

Digital Object Identifier (DOI)

  • 10.1097/shk.0000000000000198


  • eng