Inappropriately chelated iron in the cerebrospinal fluid of amyotrophic lateral sclerosis patients.


Journal Article

ALS is characterized by oxidative damage in the brain and cerebrospinal fluid, which is exerted by pro-oxidative activity of iron. Such activity of iron can be drastically increased in the presence of inappropriate iron ligands that catalyze redox cycling of iron, thereby promoting hydroxyl radical generation. The aim of our study was to determine the relative level of inappropriate iron ligands in the cerebrospinal fluid of ALS patients. To determine the levels of inappropriate iron ligands and redox activity of iron in cerebrospinal fluid (10 samples from ALS patients and 10 controls), we applied electron paramagnetic resonance spectroscopy. We have shown that cerebrospinal fluid of ALS patients comprises two-fold increased level of inappropriate iron ligands, proportionally increasing iron redox activity and hydroxyl radical production compared to controls. In conclusion, our results strongly support the pro-oxidative/detrimental role of inappropriately chelated iron in ALS pathophysiology. The identification of biomolecules that form such iron complexes and their therapeutic targeting may represent the future of ALS treatment.

Full Text

Cited Authors

  • Ignjatović, A; Stević, Z; Lavrnić, D; Nikolić-Kokić, A; Blagojević, D; Spasić, M; Spasojević, I

Published Date

  • June 2012

Published In

Volume / Issue

  • 13 / 4

Start / End Page

  • 357 - 362

PubMed ID

  • 22424123

Pubmed Central ID

  • 22424123

Electronic International Standard Serial Number (EISSN)

  • 1471-180X

International Standard Serial Number (ISSN)

  • 1748-2968

Digital Object Identifier (DOI)

  • 10.3109/17482968.2012.665929


  • eng