The negative effect of soy extract on erythrocyte membrane fluidity: an electron paramagnetic resonance study.

Published

Journal Article

A decrease of erythrocyte membrane fluidity can contribute to the pathophysiology of hypertension. Soy products, which are used as alternative therapeutics in some cardiovascular conditions, contain various isoflavones (genistein, daidzein, and their glucosides, genistin and daidzin), which can incorporate cellular membrane and change its fluidity. The aim of this study was to examine the effects of soy extract (which generally corresponds to the soy products of isoflavone composition) on erythrocyte membrane fluidity at graded depths. We used electron paramagnetic resonance spectroscopy and fatty acid spin probes (5-DS and 12-DS), the spectra of which are dependent on membrane fluidity. After being treated with soy extract, erythrocytes showed a significant (P = 0.016) decrease of membrane fluidity near the hydrophilic surface, while there were no significant changes of fluidity in deeper hydrophobic membrane regions. These results suggest that soy products containing high levels of genistein and isoflavone glucosides may not be suitable for use in hypertension because they decrease erythrocyte membrane fluidity.

Full Text

Duke Authors

Cited Authors

  • Ajdžanović, V; Spasojević, I; Sošić-Jurjević, B; Filipović, B; Trifunović, S; Sekulić, M; Milošević, V

Published Date

  • February 2011

Published In

Volume / Issue

  • 239 / 3

Start / End Page

  • 131 - 135

PubMed ID

  • 21132426

Pubmed Central ID

  • 21132426

Electronic International Standard Serial Number (EISSN)

  • 1432-1424

Digital Object Identifier (DOI)

  • 10.1007/s00232-010-9332-8

Language

  • eng

Conference Location

  • United States