Effects of 5-fluorouracil on erythrocytes in relation to its cardiotoxicity: membrane structure and functioning.

Conference Paper

In the present study, we showed that the antineoplastic drug 5-fluorouracil (5-FU) induces in vitro exposure-time/dose-dependent changes on the level of an erythrocyte's morphology, ionic balance, and membrane fluidity. These changes are partially or fully irreversible, and we suggest that they are provoked by an irreversible depletion of ATP. Because of these changes that could also occur in vivo during 5-FU infusion, a certain amount of erythrocytes with echinocytic shape and diminished ability to deliver oxygen is present in blood for longer periods of time. This renders oxygen transport and delivery more difficult, leaving the heart with an insufficient supply of oxygen, thus leading to cardiotoxicity.

Full Text

Duke Authors

Cited Authors

  • Spasojević, I; Maksimović, V; Zakrzewska, J; Bacić, G

Published Date

  • November 2005

Published In

Volume / Issue

  • 45 / 6

Start / End Page

  • 1680 - 1685

PubMed ID

  • 16309273

International Standard Serial Number (ISSN)

  • 1549-9596

Digital Object Identifier (DOI)

  • 10.1021/ci0501746

Conference Location

  • United States