Determinants of Variation in Pneumonia Rates After Coronary Artery Bypass Grafting.


Journal Article

BACKGROUND: Although conventional wisdom suggests that differences in patient risk profiles drive variability in postoperative pneumonia rates after coronary artery bypass grafting (CABG), this teaching has yet to be empirically tested. We determined to what extent patient risk factors account for hospital variation in pneumonia rates. METHODS: We studied 324,085 patients undergoing CABG between July 1, 2011, and December 31, 2013, across 998 hospitals using The Society of Thoracic Surgeons Adult Cardiac Database. We developed 5 models to estimate our incremental ability to explain hospital variation in pneumonia rates. Model 1 contained patient demographic characteristics and admission status, while Model 2 added patient risk factors. Model 3 added measures of pulmonary function, Model 4 added measures of cardiac anatomy and function and medications, and Model 5 further added measures of intraoperative and postoperative care. RESULTS: Although 9,175 patients (2.83%) experienced pneumonia, the median estimated distribution of pneumonia rates across hospitals was 2.5% (25th to 75th percentile: 1.5% to 4.0%). Wide variability in pneumonia rates was evident, with some hospitals having rates more than 6 times higher than others (10th to 90th percentile: 1.0% to 6.1%). Among all five models, Model 2 accounted for the most variability at 4.24%. In total, 2.05% of hospital variation in pneumonia rates was explained collectively by traditional patient factors, leaving 97.95% of variation unexplained. CONCLUSIONS: Our findings suggest that patient risk profiles only account for a fraction of hospital variation in pneumonia rates; enhanced understanding of other contributory factors (eg, processes of care) is required to lessen the likelihood of such nosocomial infections.

Full Text

Duke Authors

Cited Authors

  • Brescia, AA; Rankin, JS; Cyr, DD; Jacobs, JP; Prager, RL; Zhang, M; Matsouaka, RA; Harrington, SD; Dokholyan, RS; Bolling, SF; Fishstrom, A; Pasquali, SK; Shahian, DM; Likosky, DS; Michigan Society of Thoracic and Cardiovascular Surgeons Quality Collaborative,

Published Date

  • February 2018

Published In

Volume / Issue

  • 105 / 2

Start / End Page

  • 513 - 520

PubMed ID

  • 29174785

Pubmed Central ID

  • 29174785

Electronic International Standard Serial Number (EISSN)

  • 1552-6259

Digital Object Identifier (DOI)

  • 10.1016/j.athoracsur.2017.08.012


  • eng

Conference Location

  • Netherlands