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High XRCC1 protein expression is associated with poorer survival in patients with head and neck squamous cell carcinoma.

Publication ,  Journal Article
Ang, M-K; Patel, MR; Yin, X-Y; Sundaram, S; Fritchie, K; Zhao, N; Liu, Y; Freemerman, AJ; Wilkerson, MD; Walter, V; Weissler, MC; Shockley, WW ...
Published in: Clin Cancer Res
October 15, 2011

PURPOSE: We evaluated X-ray repair complementing defective repair in Chinese hamster cells 1 (XRCC1) protein in head and neck squamous cell carcinoma (HNSCC) patients in association with outcome. EXPERIMENTAL DESIGN: XRCC1 protein expression was assessed by immunohistochemical (IHC) staining of pretreatment tissue samples in 138 consecutive HNSCC patients treated with surgery (n = 31), radiation (15), surgery and radiation (23), surgery and adjuvant chemoradiation (17), primary chemoradiation (51), and palliative measures (1). RESULTS: Patients with high XRCC1 expression by IHC (n = 77) compared with patients with low XRCC1 expression (n = 60) had poorer median overall survival (OS; 41.0 months vs. OS not reached, P = 0.009) and poorer progression-free survival (28.0 months vs. 73.0 months, P = 0.031). This association was primarily due to patients who received chemoradiation (median OS of high- and low-XRCC1 expression patients, 35.5 months and not reached respectively, HR 3.48; 95% CI: 1.44-8.38; P = 0.006). In patients treated with nonchemoradiation modalities, there was no survival difference by XRCC1 expression. In multivariable analysis, high XRCC1 expression and p16(INK4a)-positive status were independently associated with survival in the overall study population (HR = 2.62; 95% CI: 1.52-4.52; P < 0.001 and HR = 0.21; 95% CI: 0.06-0.71; P = 0.012, respectively) and among chemoradiation patients (HR = 6.02; 95% CI: 2.36-15.37; P < 0.001 and HR = 0.26; 95% CI: 0.08-0.92, respectively; P = 0.037). CONCLUSIONS: In HNSCC, high XRCC1 protein expression is associated with poorer survival, particularly in patients receiving chemoradiation. Future validation of these findings may enable identification of HNSCC expressing patients who benefit from chemoradiation treatment.

Duke Scholars

Published In

Clin Cancer Res

DOI

EISSN

1557-3265

Publication Date

October 15, 2011

Volume

17

Issue

20

Start / End Page

6542 / 6552

Location

United States

Related Subject Headings

  • X-ray Repair Cross Complementing Protein 1
  • Squamous Cell Carcinoma of Head and Neck
  • Prognosis
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Humans
  • Head and Neck Neoplasms
  • Gene Knockout Techniques
  • Female
 

Citation

APA
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MLA
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Ang, M.-K., Patel, M. R., Yin, X.-Y., Sundaram, S., Fritchie, K., Zhao, N., … Hayes, D. N. (2011). High XRCC1 protein expression is associated with poorer survival in patients with head and neck squamous cell carcinoma. Clin Cancer Res, 17(20), 6542–6552. https://doi.org/10.1158/1078-0432.CCR-10-1604
Ang, Mei-Kim, Mihir R. Patel, Xiao-Ying Yin, Sneha Sundaram, Karen Fritchie, Ni Zhao, Yufeng Liu, et al. “High XRCC1 protein expression is associated with poorer survival in patients with head and neck squamous cell carcinoma.Clin Cancer Res 17, no. 20 (October 15, 2011): 6542–52. https://doi.org/10.1158/1078-0432.CCR-10-1604.
Ang M-K, Patel MR, Yin X-Y, Sundaram S, Fritchie K, Zhao N, et al. High XRCC1 protein expression is associated with poorer survival in patients with head and neck squamous cell carcinoma. Clin Cancer Res. 2011 Oct 15;17(20):6542–52.
Ang, Mei-Kim, et al. “High XRCC1 protein expression is associated with poorer survival in patients with head and neck squamous cell carcinoma.Clin Cancer Res, vol. 17, no. 20, Oct. 2011, pp. 6542–52. Pubmed, doi:10.1158/1078-0432.CCR-10-1604.
Ang M-K, Patel MR, Yin X-Y, Sundaram S, Fritchie K, Zhao N, Liu Y, Freemerman AJ, Wilkerson MD, Walter V, Weissler MC, Shockley WW, Couch ME, Zanation AM, Hackman T, Chera BS, Harris SL, Miller CR, Thorne LB, Hayward MC, Funkhouser WK, Olshan AF, Shores CG, Makowski L, Hayes DN. High XRCC1 protein expression is associated with poorer survival in patients with head and neck squamous cell carcinoma. Clin Cancer Res. 2011 Oct 15;17(20):6542–6552.

Published In

Clin Cancer Res

DOI

EISSN

1557-3265

Publication Date

October 15, 2011

Volume

17

Issue

20

Start / End Page

6542 / 6552

Location

United States

Related Subject Headings

  • X-ray Repair Cross Complementing Protein 1
  • Squamous Cell Carcinoma of Head and Neck
  • Prognosis
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Humans
  • Head and Neck Neoplasms
  • Gene Knockout Techniques
  • Female