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United States Population-Based Estimates of Patient-Reported Outcomes Measurement Information System Symptom and Functional Status Reference Values for Individuals With Cancer.

Publication ,  Journal Article
Jensen, RE; Potosky, AL; Moinpour, CM; Lobo, T; Cella, D; Hahn, EA; Thissen, D; Smith, AW; Ahn, J; Luta, G; Reeve, BB
Published in: J Clin Oncol
June 10, 2017

Purpose To estimate cancer population-based reference values in the United States for eight PROMIS (Patient-Reported Outcomes Measurement Information System) domains by age and stage of disease. Patients and Methods For the Measuring Your Health (MY-Health) study, persons newly diagnosed with cancer (prostate, colorectal, non-small-cell lung, non-Hodgkin lymphoma, breast, uterine, or cervical) from 2010 to 2012 (N = 5,284) were recruited through the National Cancer Institute's SEER Program. Participants were mailed surveys 6 to 13 months after diagnosis. Raking by race/ethnicity, age, and stage generated weighted average PROMIS scores for pain interference, fatigue, anxiety, depression, sleep disturbance, physical function, ability to participate in social roles, and cognitive function. PROMIS measures are standardized to a T-score metric, with a score of 50 representing the general US population mean. Clinically meaningful differences were defined as a 3-point difference in scores. Results Several reference values (means) for patients with cancer were worse than the general United States population norms of 50. These include pain interference (52.4), fatigue (52.2), and physical function (44.1). Reference values were highest (ie, showed greatest symptom burden) in lung cancer (pain interference, 55.5; fatigue, 57.3; depression, 51.4) and cervical cancer (anxiety, 53.2; sleep disturbance, 53.4). Reference values for patients age 65 to 84 years reported lower sleep disturbance, anxiety, and depression, and better cognitive function than younger patients. Cancer reference values were poorer among those with advanced disease compared with patients with limited or no evidence of disease, specifically physical function (41.1 v 46.6, respectively), fatigue (55.8 v 50.2, respectively), and pain interference (55.2 v 50.9, respectively). Conclusion In a large, population-based sample of patients with recently diagnosed cancer, we observed symptom severity and functional deficits by age, stage, and cancer type consistent with the expected impact of cancer diagnosis and treatment. These United States cancer reference values can help facilitate interpretation of the PROMIS domain scores in research studies or in clinical applications that measure and evaluate the symptom and functional burden patients with cancer experience after initial treatment.

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Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

June 10, 2017

Volume

35

Issue

17

Start / End Page

1913 / 1920

Location

United States

Related Subject Headings

  • United States
  • Self Report
  • SEER Program
  • Reference Values
  • Patient Outcome Assessment
  • Outcome Assessment, Health Care
  • Oncology & Carcinogenesis
  • Neoplasms
  • Male
  • Information Systems
 

Citation

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Jensen, R. E., Potosky, A. L., Moinpour, C. M., Lobo, T., Cella, D., Hahn, E. A., … Reeve, B. B. (2017). United States Population-Based Estimates of Patient-Reported Outcomes Measurement Information System Symptom and Functional Status Reference Values for Individuals With Cancer. J Clin Oncol, 35(17), 1913–1920. https://doi.org/10.1200/JCO.2016.71.4410
Jensen, Roxanne E., Arnold L. Potosky, Carol M. Moinpour, Tania Lobo, David Cella, Elizabeth A. Hahn, David Thissen, et al. “United States Population-Based Estimates of Patient-Reported Outcomes Measurement Information System Symptom and Functional Status Reference Values for Individuals With Cancer.J Clin Oncol 35, no. 17 (June 10, 2017): 1913–20. https://doi.org/10.1200/JCO.2016.71.4410.
Jensen, Roxanne E., et al. “United States Population-Based Estimates of Patient-Reported Outcomes Measurement Information System Symptom and Functional Status Reference Values for Individuals With Cancer.J Clin Oncol, vol. 35, no. 17, June 2017, pp. 1913–20. Pubmed, doi:10.1200/JCO.2016.71.4410.
Jensen RE, Potosky AL, Moinpour CM, Lobo T, Cella D, Hahn EA, Thissen D, Smith AW, Ahn J, Luta G, Reeve BB. United States Population-Based Estimates of Patient-Reported Outcomes Measurement Information System Symptom and Functional Status Reference Values for Individuals With Cancer. J Clin Oncol. 2017 Jun 10;35(17):1913–1920.

Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

June 10, 2017

Volume

35

Issue

17

Start / End Page

1913 / 1920

Location

United States

Related Subject Headings

  • United States
  • Self Report
  • SEER Program
  • Reference Values
  • Patient Outcome Assessment
  • Outcome Assessment, Health Care
  • Oncology & Carcinogenesis
  • Neoplasms
  • Male
  • Information Systems