Recommended patient-reported core set of symptoms to measure in prostate cancer treatment trials.

Journal Article (Journal Article;Review;Systematic Review)

The National Cancer Institute (NCI) Symptom Management and Health-Related Quality of Life Steering Committee convened four working groups to recommend core sets of patient-reported outcomes to be routinely incorporated in clinical trials. The Prostate Cancer Working Group included physicians, researchers, and a patient advocate. The group's process included 1) a systematic literature review to determine the prevalence and severity of symptoms, 2) a multistakeholder meeting sponsored by the NCI to review the evidence and build consensus, and 3) a postmeeting expert panel synthesis of findings to finalize recommendations. Five domains were recommended for localized prostate cancer: urinary incontinence, urinary obstruction and irritation, bowel-related symptoms, sexual dysfunction, and hormonal symptoms. Four domains were recommended for advanced prostate cancer: pain, fatigue, mental well-being, and physical well-being. Additional domains for consideration include decisional regret, satisfaction with care, and anxiety related to prostate cancer. These recommendations have been endorsed by the NCI for implementation.

Full Text

Duke Authors

Cited Authors

  • Chen, RC; Chang, P; Vetter, RJ; Lukka, H; Stokes, WA; Sanda, MG; Watkins-Bruner, D; Reeve, BB; Sandler, HM

Published Date

  • July 2014

Published In

Volume / Issue

  • 106 / 7

PubMed ID

  • 25006192

Pubmed Central ID

  • PMC4192044

Electronic International Standard Serial Number (EISSN)

  • 1460-2105

Digital Object Identifier (DOI)

  • 10.1093/jnci/dju132


  • eng

Conference Location

  • United States