Recommended patient-reported core set of symptoms to measure in head and neck cancer treatment trials.

Published

Journal Article (Review)

We identified a standard core set of patient-reported symptoms and health-related quality-of-life (HRQOL) domains to be assessed in head and neck (H&N) cancer clinical trials. The core symptom and HRQOL domain scores were used to guide recommendations by a working group of experts as part of a National Cancer Institute Symptom Management and HRQOL Clinical Trials Planning Meeting. A PubMed search was conducted using the search terms of "health-related quality of life" and "head & neck cancer," limited to publications from January 1, 2000, to December 31, 2010. Fifty-four articles were used to guide the choice of recommendations. Twenty-nine symptoms and nine domains were identified, from which 12 H&N-specific core symptoms and HRQOL domains were recommended: swallowing, oral pain, skin changes, dry mouth, dental health, opening mouth/trismus, taste, excess/thick mucous/saliva, shoulder disability/motion, voice/hoarseness, social domain, and functional domain. This core set of 12 H&N-specific, patient-reported symptoms and HRQOL domains should be assessed in future H&N cancer clinical trials.

Full Text

Duke Authors

Cited Authors

  • Chera, BS; Eisbruch, A; Murphy, BA; Ridge, JA; Gavin, P; Reeve, BB; Bruner, DW; Movsas, B

Published Date

  • July 8, 2014

Published In

Volume / Issue

  • 106 / 7

PubMed ID

  • 25006189

Pubmed Central ID

  • 25006189

Electronic International Standard Serial Number (EISSN)

  • 1460-2105

International Standard Serial Number (ISSN)

  • 0027-8874

Digital Object Identifier (DOI)

  • 10.1093/jnci/dju127

Language

  • eng