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A primer on concentrated insulins: what an internist should know.

Publication ,  Journal Article
Barnosky, A; Shah, L; Meah, F; Emanuele, N; Emanuele, MA; Mazhari, A
Published in: Postgrad Med
May 2016

The common insulin concentration in most preparations of insulin is 100 units per mL or U-100. Human regular U-500 insulin was the first concentrated insulin introduced and it has been available in the United States since the 1950s. Humulin R is the only human regular U-500 available on the market. Human regular U-500 is five times more concentrated than U-100 and because of its pharmacodynamic properties, works as both a basal and a bolus insulin. Human regular U500 allows for delivery of a larger insulin dose with a smaller volume leading to better absorption compared to U-100 and has traditionally been used in patients with moderate to severe insulin resistance. More recently other forms of concentrated insulin have become available and the newer concentrated insulin preparations can be used in diabetic patients with or without insulin resistance. Our intent is to provide primary care physicians with a review of the pharmacology and current literature on concentrated insulins as well as recommendations for patient selection, dose initiation, and dose adjustment.

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Published In

Postgrad Med

DOI

EISSN

1941-9260

Publication Date

May 2016

Volume

128

Issue

4

Start / End Page

381 / 390

Location

England

Related Subject Headings

  • Pregnancy in Diabetics
  • Pregnancy
  • Patient Selection
  • Insulin, Long-Acting
  • Insulin Resistance
  • Insulin Lispro
  • Insulin Glargine
  • Insulin
  • Hypoglycemic Agents
  • Hypoglycemia
 

Citation

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Barnosky, A., Shah, L., Meah, F., Emanuele, N., Emanuele, M. A., & Mazhari, A. (2016). A primer on concentrated insulins: what an internist should know. Postgrad Med, 128(4), 381–390. https://doi.org/10.1080/00325481.2016.1159909
Barnosky, Adrienne, Lisa Shah, Farah Meah, Nicholas Emanuele, Mary Ann Emanuele, and Alaleh Mazhari. “A primer on concentrated insulins: what an internist should know.Postgrad Med 128, no. 4 (May 2016): 381–90. https://doi.org/10.1080/00325481.2016.1159909.
Barnosky A, Shah L, Meah F, Emanuele N, Emanuele MA, Mazhari A. A primer on concentrated insulins: what an internist should know. Postgrad Med. 2016 May;128(4):381–90.
Barnosky, Adrienne, et al. “A primer on concentrated insulins: what an internist should know.Postgrad Med, vol. 128, no. 4, May 2016, pp. 381–90. Pubmed, doi:10.1080/00325481.2016.1159909.
Barnosky A, Shah L, Meah F, Emanuele N, Emanuele MA, Mazhari A. A primer on concentrated insulins: what an internist should know. Postgrad Med. 2016 May;128(4):381–390.

Published In

Postgrad Med

DOI

EISSN

1941-9260

Publication Date

May 2016

Volume

128

Issue

4

Start / End Page

381 / 390

Location

England

Related Subject Headings

  • Pregnancy in Diabetics
  • Pregnancy
  • Patient Selection
  • Insulin, Long-Acting
  • Insulin Resistance
  • Insulin Lispro
  • Insulin Glargine
  • Insulin
  • Hypoglycemic Agents
  • Hypoglycemia