Changes in hunger and fullness in relation to gut peptides before and after 8 weeks of alternate day fasting.

Journal Article (Journal Article)

BACKGROUND & AIMS: Alternate day fasting (ADF; 25% energy intake "fast day", alternated with an ad libitum intake "feed day") is effective for weight loss. Whether or not ADF modulates hunger, fullness and gut peptides in a way that enhances dietary compliance and weight loss, remains unknown. Accordingly, this study examined the effect of ADF on postprandial appetite ratings and gut peptides. METHODS: Obese subjects (n = 59) participated in an 8-week ADF protocol where food was provided on the fast day. RESULTS: Body weight decreased (P < 0.0001) by 3.9 ± 0.6 kg after 8 weeks of diet. Reductions (P < 0.05) in fat mass (-2.2 ± 0.2 kg), fat free mass (-1.4 ± 0.2 kg), visceral fat mass (-0.1 ± 0.1 kg), and resting metabolic rate (RMR; -104 ± 28 kcal/day) were also observed. Fasting leptin and insulin decreased (P < 0.05), while AUC ghrelin levels increased (P < 0.05). Despite these metabolic changes, there was no increase in subjective hunger by the end of the study. Furthermore, fullness and PYY increased (P < 0.05). Fat free mass and RMR were not related to hunger or ghrelin at any time point. CONCLUSION: These findings suggest that the absence of a compensatory increase in hunger in conjunction with an increase in sensations of fullness may contribute to the weight loss efficacy of an 8-week ADF regimen.

Full Text

Duke Authors

Cited Authors

  • Hoddy, KK; Gibbons, C; Kroeger, CM; Trepanowski, JF; Barnosky, A; Bhutani, S; Gabel, K; Finlayson, G; Varady, KA

Published Date

  • December 2016

Published In

Volume / Issue

  • 35 / 6

Start / End Page

  • 1380 - 1385

PubMed ID

  • 27062219

Electronic International Standard Serial Number (EISSN)

  • 1532-1983

Digital Object Identifier (DOI)

  • 10.1016/j.clnu.2016.03.011


  • eng

Conference Location

  • England