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Associations of aortic distensibility and arterial elasticity with long-term visit-to-visit blood pressure variability: the Multi-Ethnic Study of Atherosclerosis (MESA).

Publication ,  Journal Article
Shimbo, D; Shea, S; McClelland, RL; Viera, AJ; Mann, D; Newman, J; Lima, J; Polak, JF; Psaty, BM; Muntner, P
Published in: Am J Hypertens
July 2013

BACKGROUND: Although higher visit-to-visit variability (VVV) of blood pressure (BP) is associated with increased cardiovascular disease risk, the physiological basis for VVV of BP is incompletely understood. METHODS: We examined the associations of aortic distensibility (assessed by magnetic resonance imaging) and artery elasticity indices (determined by radial artery pulse contour analysis) with VVV of BP in 2,640 and 4,560 participants, respectively, from the Multi-Ethnic Study of Atherosclerosis. Arterial measures were obtained at exam 1. BP readings were taken at exam 1 and at 3 follow-up visits at 18-month intervals (exams 2, 3, and 4). VVV was defined as the SD about each participant's mean systolic BP (SBP) across visits. RESULTS: The mean SDs of SBP were inversely associated with aortic distensibility: 7.7, 9.9, 10.9, and 13.2mm Hg for quartiles 4, 3, 2, and 1 of aortic distensibility, respectively (P trend < 0.001). This association remained significant after adjustment for demographics, cardiovascular risk factors, mean SBP, and antihypertensive medication use (P trend < 0.01). In a fully adjusted model, lower quartiles of large artery and small artery elasticity (LAE and SAE) indices were also associated with higher mean SD of SBP (P trend = 0.02 for LAE; P trend < 0.001 for SAE). CONCLUSIONS: In this multiethnic cohort, functional alterations of central and peripheral arteries were associated with greater long-term VVV of SBP.

Duke Scholars

Published In

Am J Hypertens

DOI

EISSN

1941-7225

Publication Date

July 2013

Volume

26

Issue

7

Start / End Page

896 / 902

Location

United States

Related Subject Headings

  • United States
  • Risk Factors
  • Prevalence
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging, Cine
  • Humans
  • Follow-Up Studies
  • Female
  • Ethnicity
 

Citation

APA
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ICMJE
MLA
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Shimbo, D., Shea, S., McClelland, R. L., Viera, A. J., Mann, D., Newman, J., … Muntner, P. (2013). Associations of aortic distensibility and arterial elasticity with long-term visit-to-visit blood pressure variability: the Multi-Ethnic Study of Atherosclerosis (MESA). Am J Hypertens, 26(7), 896–902. https://doi.org/10.1093/ajh/hpt040
Shimbo, Daichi, Steven Shea, Robyn L. McClelland, Anthony J. Viera, Devin Mann, Jonathan Newman, Joao Lima, Joseph F. Polak, Bruce M. Psaty, and Paul Muntner. “Associations of aortic distensibility and arterial elasticity with long-term visit-to-visit blood pressure variability: the Multi-Ethnic Study of Atherosclerosis (MESA).Am J Hypertens 26, no. 7 (July 2013): 896–902. https://doi.org/10.1093/ajh/hpt040.
Shimbo, Daichi, et al. “Associations of aortic distensibility and arterial elasticity with long-term visit-to-visit blood pressure variability: the Multi-Ethnic Study of Atherosclerosis (MESA).Am J Hypertens, vol. 26, no. 7, July 2013, pp. 896–902. Pubmed, doi:10.1093/ajh/hpt040.
Shimbo D, Shea S, McClelland RL, Viera AJ, Mann D, Newman J, Lima J, Polak JF, Psaty BM, Muntner P. Associations of aortic distensibility and arterial elasticity with long-term visit-to-visit blood pressure variability: the Multi-Ethnic Study of Atherosclerosis (MESA). Am J Hypertens. 2013 Jul;26(7):896–902.
Journal cover image

Published In

Am J Hypertens

DOI

EISSN

1941-7225

Publication Date

July 2013

Volume

26

Issue

7

Start / End Page

896 / 902

Location

United States

Related Subject Headings

  • United States
  • Risk Factors
  • Prevalence
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging, Cine
  • Humans
  • Follow-Up Studies
  • Female
  • Ethnicity