Copper-catalyzed aminoalkynylation of alkenes with hypervalent iodine reagents.

Journal Article (Journal Article)

A copper-catalyzed aminoalkynylation of alkenes is achieved with ethynylbenziodoxolone (EBX) reagents under mild conditions with only 1 mol% copper catalyst. This transformation allows for rapid construction of diverse important azahetereocycles and installation of valuable alkyne groups in one step. The developed method features remarkable substrate scope for both terminal and internal alkenes as well as different alkynyl groups, presenting great potential for broad applications in synthesis, bioconjugation, and molecular imaging.

Full Text

Duke Authors

Cited Authors

  • Shen, K; Wang, Q

Published Date

  • December 2017

Published In

Volume / Issue

  • 8 / 12

Start / End Page

  • 8265 - 8270

PubMed ID

  • 29568474

Pubmed Central ID

  • PMC5857935

Electronic International Standard Serial Number (EISSN)

  • 2041-6539

International Standard Serial Number (ISSN)

  • 2041-6520

Digital Object Identifier (DOI)

  • 10.1039/c7sc03420b


  • eng