A craniofacial-specific monosynaptic circuit enables heightened affective pain.

Published

Journal Article

Humans often rank craniofacial pain as more severe than body pain. Evidence suggests that a stimulus of the same intensity induces stronger pain in the face than in the body. However, the underlying neural circuitry for the differential processing of facial versus bodily pain remains unknown. Interestingly, the lateral parabrachial nucleus (PBL), a critical node in the affective pain circuit, is activated more strongly by noxious stimulation of the face than of the hindpaw. Using a novel activity-dependent technology called CANE developed in our laboratory, we identified and selectively labeled noxious-stimulus-activated PBL neurons and performed comprehensive anatomical input-output mapping. Surprisingly, we uncovered a hitherto uncharacterized monosynaptic connection between cranial sensory neurons and the PBL-nociceptive neurons. Optogenetic activation of this monosynaptic craniofacial-to-PBL projection induced robust escape and avoidance behaviors and stress calls, whereas optogenetic silencing specifically reduced facial nociception. The monosynaptic circuit revealed here provides a neural substrate for heightened craniofacial affective pain.

Full Text

Duke Authors

Cited Authors

  • Rodriguez, E; Sakurai, K; Xu, J; Chen, Y; Toda, K; Zhao, S; Han, B-X; Ryu, D; Yin, H; Liedtke, W; Wang, F

Published Date

  • December 2017

Published In

Volume / Issue

  • 20 / 12

Start / End Page

  • 1734 - 1743

PubMed ID

  • 29184209

Pubmed Central ID

  • 29184209

Electronic International Standard Serial Number (EISSN)

  • 1546-1726

Digital Object Identifier (DOI)

  • 10.1038/s41593-017-0012-1

Language

  • eng

Conference Location

  • United States