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Volumetric analysis of IDH-mutant lower-grade glioma: a natural history study of tumor growth rates before and after treatment.

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Huang, RY; Young, RJ; Ellingson, BM; Veeraraghavan, H; Wang, W; Tixier, F; Um, H; Nawaz, R; Luks, T; Kim, J; Gerstner, ER; Schiff, D; Wen, PY ...
Published in: Neuro Oncol
December 18, 2020

BACKGROUND: Lower-grade gliomas (LGGs) with isocitrate dehydrogenase 1 and/or 2 (IDH1/2) mutations have long survival times, making evaluation of treatment efficacy difficult. We investigated the volumetric growth rate of IDH mutant gliomas before and after treatment with established glioma therapies to determine whether a significant change in growth rate could be documented and perhaps be used in the future to evaluate treatment response to investigational agents in LGG trials. METHODS: In this multicenter retrospective study, 230 adult patients with IDH1/2 mutated LGGs (World Health Organization grade II or III) undergoing surgery, radiation, or chemotherapy for progressive non-enhancing tumor were identified. Subjects were required to have 3 MRI scans containing T2/fluid attenuated inversion recovery imaging spanning a minimum of 6 months prior to treatment. A mixed-effect model was used to estimate tumor growth prior to treatment. A subset of 95 patients who received chemotherapy, radiotherapy, or chemoradiotherapy and had 2 posttreatment imaging time points available were evaluated for change in pre- and posttreatment volumetric growth rates using a piecewise mixed model. RESULTS: The pretreatment volumetric growth rate across all 230 patients was 27.37%/180 days (95% CI: [23.36%, 31.51%]). In the 95 patients with both pre- and posttreatment scans available, there was a significant difference in volumetric growth rates before (26.63%/180 days, 95% CI: [19.31%, 34.40%]) and after treatment (-15.24% /180 days, 95% CI: [-21.37%, -8.62%]) (P < 0.0001). The growth rates for patient subgroup with 1p/19q codeletion (N = 118) was significantly slower than the rate of the 1p/19q non-codeleted group (N = 68) (22.84% vs 35.49%, P = 0.0108). CONCLUSION: In this study, we evaluated the growth rates of IDH mutant gliomas before and after standard therapy. Further study is needed to establish whether a change in growth rate is associated with patient survival and its use as a surrogate endpoint in clinical trials for IDH mutant LGGs.

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Published In

Neuro Oncol

DOI

EISSN

1523-5866

Publication Date

December 18, 2020

Volume

22

Issue

12

Start / End Page

1822 / 1830

Location

England

Related Subject Headings

  • Retrospective Studies
  • Oncology & Carcinogenesis
  • Neoplasm Grading
  • Mutation
  • Magnetic Resonance Imaging
  • Isocitrate Dehydrogenase
  • Humans
  • Glioma
  • Brain Neoplasms
  • Adult
 

Citation

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Huang, R. Y., Young, R. J., Ellingson, B. M., Veeraraghavan, H., Wang, W., Tixier, F., … Wen, P. Y. (2020). Volumetric analysis of IDH-mutant lower-grade glioma: a natural history study of tumor growth rates before and after treatment. In Neuro Oncol (Vol. 22, pp. 1822–1830). England. https://doi.org/10.1093/neuonc/noaa105
Huang, Raymond Y., Robert J. Young, Benjamin M. Ellingson, Harini Veeraraghavan, Wei Wang, Florent Tixier, Hyemin Um, et al. “Volumetric analysis of IDH-mutant lower-grade glioma: a natural history study of tumor growth rates before and after treatment.” In Neuro Oncol, 22:1822–30, 2020. https://doi.org/10.1093/neuonc/noaa105.
Huang RY, Young RJ, Ellingson BM, Veeraraghavan H, Wang W, Tixier F, et al. Volumetric analysis of IDH-mutant lower-grade glioma: a natural history study of tumor growth rates before and after treatment. In: Neuro Oncol. 2020. p. 1822–30.
Huang, Raymond Y., et al. “Volumetric analysis of IDH-mutant lower-grade glioma: a natural history study of tumor growth rates before and after treatment.Neuro Oncol, vol. 22, no. 12, 2020, pp. 1822–30. Pubmed, doi:10.1093/neuonc/noaa105.
Huang RY, Young RJ, Ellingson BM, Veeraraghavan H, Wang W, Tixier F, Um H, Nawaz R, Luks T, Kim J, Gerstner ER, Schiff D, Peters KB, Mellinghoff IK, Chang SM, Cloughesy TF, Wen PY. Volumetric analysis of IDH-mutant lower-grade glioma: a natural history study of tumor growth rates before and after treatment. Neuro Oncol. 2020. p. 1822–1830.
Journal cover image

Published In

Neuro Oncol

DOI

EISSN

1523-5866

Publication Date

December 18, 2020

Volume

22

Issue

12

Start / End Page

1822 / 1830

Location

England

Related Subject Headings

  • Retrospective Studies
  • Oncology & Carcinogenesis
  • Neoplasm Grading
  • Mutation
  • Magnetic Resonance Imaging
  • Isocitrate Dehydrogenase
  • Humans
  • Glioma
  • Brain Neoplasms
  • Adult