Dynamic changes in retinal vessel diameter during acute hyperglycemia in type 1 diabetes.
Published
Journal Article
AIMS: To investigate changes in retinal vessel diameter during acute hyperglycemia in patients with type 1 diabetes. METHODS: We conducted a study on 11 subjects with type 1 diabetes. Euglycemia was maintained for 3h followed by induction of hyperglycemia and simultaneous bolus of rapid acting insulin. Two fundus photos were captured during euglycemia and five fundus photos, blood glucose and blood pressure were taken every 30min for 2.5h post-prandial. Central retinal artery equivalent (CRAE) and central retinal vein equivalent (CRVE) were measured over the study visit and examined using generalized linear mixed models. RESULTS: In a multivariate mixed model, mean CRAE and CRVE were reduced at 90min post-prandial in both zones B and C. In repeated measures analysis, arterioles exhibited a significant association with change in vessel caliber per change in blood glucose. Inconsistent effects of blood pressure on vessel diameter were also measured. CONCLUSIONS: We document a change in retinal vessel diameter during acute hyperglycemia in persons with type 1 diabetes. Larger controlled studies are required to further investigate this phenomenon and to more accurately assess if hyperglycemia has direct effects on retinal vessel diameter.
Full Text
Duke Authors
Cited Authors
- Bucca, BC; Maahs, DM; Snell-Bergeon, JK; Hokanson, J; Rinella, S; Bishop, F; Boufard, A; Homann, J; Cheung, CY; Wong, TY
Published Date
- February 2018
Published In
Volume / Issue
- 32 / 2
Start / End Page
- 234 - 239
PubMed ID
- 29174301
Pubmed Central ID
- 29174301
Electronic International Standard Serial Number (EISSN)
- 1873-460X
Digital Object Identifier (DOI)
- 10.1016/j.jdiacomp.2017.10.001
Language
- eng
Conference Location
- United States