Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia.

Journal Article (Journal Article;Multicenter Study)

BACKGROUND: Many studies report smaller hippocampal and amygdala volumes in posttraumatic stress disorder (PTSD), but findings have not always been consistent. Here, we present the results of a large-scale neuroimaging consortium study on PTSD conducted by the Psychiatric Genomics Consortium (PGC)-Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) PTSD Working Group. METHODS: We analyzed neuroimaging and clinical data from 1868 subjects (794 PTSD patients) contributed by 16 cohorts, representing the largest neuroimaging study of PTSD to date. We assessed the volumes of eight subcortical structures (nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen, thalamus, and lateral ventricle). We used a standardized image-analysis and quality-control pipeline established by the ENIGMA consortium. RESULTS: In a meta-analysis of all samples, we found significantly smaller hippocampi in subjects with current PTSD compared with trauma-exposed control subjects (Cohen's d = -0.17, p = .00054), and smaller amygdalae (d = -0.11, p = .025), although the amygdala finding did not survive a significance level that was Bonferroni corrected for multiple subcortical region comparisons (p < .0063). CONCLUSIONS: Our study is not subject to the biases of meta-analyses of published data, and it represents an important milestone in an ongoing collaborative effort to examine the neurobiological underpinnings of PTSD and the brain's response to trauma.

Full Text

Duke Authors

Cited Authors

  • Logue, MW; van Rooij, SJH; Dennis, EL; Davis, SL; Hayes, JP; Stevens, JS; Densmore, M; Haswell, CC; Ipser, J; Koch, SBJ; Korgaonkar, M; Lebois, LAM; Peverill, M; Baker, JT; Boedhoe, PSW; Frijling, JL; Gruber, SA; Harpaz-Rotem, I; Jahanshad, N; Koopowitz, S; Levy, I; Nawijn, L; O'Connor, L; Olff, M; Salat, DH; Sheridan, MA; Spielberg, JM; van Zuiden, M; Winternitz, SR; Wolff, JD; Wolf, EJ; Wang, X; Wrocklage, K; Abdallah, CG; Bryant, RA; Geuze, E; Jovanovic, T; Kaufman, ML; King, AP; Krystal, JH; Lagopoulos, J; Bennett, M; Lanius, R; Liberzon, I; McGlinchey, RE; McLaughlin, KA; Milberg, WP; Miller, MW; Ressler, KJ; Veltman, DJ; Stein, DJ; Thomaes, K; Thompson, PM; Morey, RA

Published Date

  • February 1, 2018

Published In

Volume / Issue

  • 83 / 3

Start / End Page

  • 244 - 253

PubMed ID

  • 29217296

Pubmed Central ID

  • PMC5951719

Electronic International Standard Serial Number (EISSN)

  • 1873-2402

Digital Object Identifier (DOI)

  • 10.1016/j.biopsych.2017.09.006


  • eng

Conference Location

  • United States