The Skaergaard intrusion of East Greenland is characterized by unusually low sulfur (S) and high metal/S ratios. Explanations range from S lost during cooling to suggestions that low S was characteristic of the original magma. A nonequilibrium thermodynamic analysis of modal variations in the chilled margin and Lower Zone is consistent with a late stage reaction of chalcopyrite → magnetite ± bornite + Slost; the pre-reaction assemblage was dominated by chalcopyrite with a Cu:S mass ratio ~1:1, a ratio unusually low for an undegassed hotspot basalt. A comparison with other hotspot and flood basalt provinces suggests that these magmas can lose significant S to recirculating shallow-level degassed magma. It is concluded that degassing of the parent Skaergaard magma prior to solidification and continuous vapor loss during crystallization both contributed to the overall high metal/S ratios of the Skaergaard system.