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Macular thickness profile and diabetic retinopathy: the Singapore Epidemiology of Eye Diseases Study.

Publication ,  Journal Article
Dai, W; Tham, YC; Cheung, N; Yasuda, M; Tan, NYQ; Cheung, CY; Wang, JJ; Mitchell, P; Sabanayagam, C; Wong, T-Y; Cheng, C-Y
Published in: Br J Ophthalmol
August 2018

BACKGROUND: To evaluate retinal thickness profiles in eyes with and without diabetic retinopathy (DR) using spectral-domain optical coherence tomography (SD-OCT) among individuals with diabetes. METHODS: Participants were recruited from the Singapore Epidemiology of Eye Diseases Study, a population-based study among Chinese, Malays and Indians aged 40 years or older residing in Singapore. All participants underwent standardised systemic and ophthalmic examinations. Average thickness of the macula, ganglion cell-inner plexiform layer and outer retina layer (from the outer plexiform layer to the retinal pigment epithelium layer) were measured using SD-OCT. DR status and severity were graded based on fundus photographs using the modified Airlie House classification system. Participants with macular oedema were excluded. RESULTS: 2240 eyes from 1280 participants were included. Of these, 1764 (78.7%) eyes had no DR, 351 (15.7%) eyes had minimal or mild DR and 125 (5.6%) eyes had moderate or worse DR. After adjusting for age, gender, ethnicity, axial length, hypertension, glycated haemoglobin, body mass index, total cholesterol and diabetes duration, eyes with DR had thicker macula (245.44 µm vs 243.04 µm, P=0.03) and outer retina (124.26 µm vs 123.08 µm, P=0.01) than eyes without DR. When stratified by DR severity, thicker macula (250.24 µm vs 242.88 µm, P=0.011) and outer retina (126.4 µm vs 123.0 μm, P=0.006) were observed in eyes with moderate or worse, but not minimal or mild DR, compared with eyes without DR. CONCLUSIONS: Even in the absence of macular oedema, eyes with DR, particularly those with more severe DR, had thicker macular and outer retinal layers than eyes without DR.

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Published In

Br J Ophthalmol

DOI

EISSN

1468-2079

Publication Date

August 2018

Volume

102

Issue

8

Start / End Page

1072 / 1076

Location

England

Related Subject Headings

  • Tomography, Optical Coherence
  • Singapore
  • Organ Size
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Macula Lutea
  • Humans
  • Glycated Hemoglobin
  • Female
 

Citation

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Chicago
ICMJE
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Dai, W., Tham, Y. C., Cheung, N., Yasuda, M., Tan, N. Y. Q., Cheung, C. Y., … Cheng, C.-Y. (2018). Macular thickness profile and diabetic retinopathy: the Singapore Epidemiology of Eye Diseases Study. Br J Ophthalmol, 102(8), 1072–1076. https://doi.org/10.1136/bjophthalmol-2017-310959
Dai, Wei, Yih Chung Tham, Ning Cheung, Masayuki Yasuda, Nicholas Y. Q. Tan, Carol Y. Cheung, Jie Jin Wang, et al. “Macular thickness profile and diabetic retinopathy: the Singapore Epidemiology of Eye Diseases Study.Br J Ophthalmol 102, no. 8 (August 2018): 1072–76. https://doi.org/10.1136/bjophthalmol-2017-310959.
Dai W, Tham YC, Cheung N, Yasuda M, Tan NYQ, Cheung CY, et al. Macular thickness profile and diabetic retinopathy: the Singapore Epidemiology of Eye Diseases Study. Br J Ophthalmol. 2018 Aug;102(8):1072–6.
Dai, Wei, et al. “Macular thickness profile and diabetic retinopathy: the Singapore Epidemiology of Eye Diseases Study.Br J Ophthalmol, vol. 102, no. 8, Aug. 2018, pp. 1072–76. Pubmed, doi:10.1136/bjophthalmol-2017-310959.
Dai W, Tham YC, Cheung N, Yasuda M, Tan NYQ, Cheung CY, Wang JJ, Mitchell P, Sabanayagam C, Wong T-Y, Cheng C-Y. Macular thickness profile and diabetic retinopathy: the Singapore Epidemiology of Eye Diseases Study. Br J Ophthalmol. 2018 Aug;102(8):1072–1076.

Published In

Br J Ophthalmol

DOI

EISSN

1468-2079

Publication Date

August 2018

Volume

102

Issue

8

Start / End Page

1072 / 1076

Location

England

Related Subject Headings

  • Tomography, Optical Coherence
  • Singapore
  • Organ Size
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Macula Lutea
  • Humans
  • Glycated Hemoglobin
  • Female