Association of APOE and other genetic polymorphisms with prospective concussion risk in a prospective cohort study of college athletes

Published

Conference Paper

© 2014 IEEE. The management of sports concussion and an understanding of its risk factors are major foci i. The literature on athletic injury. Althoug. There is known influence of some genetic polymorphisms (GPs), such as APOE an. The APOE promoter, on traumatic brain injury (TBI) outcome in non-athletic populations, very little work has focused o. The rol. These GPs may play in sports concussion. We completed a large (n=3274) multi-center prospective cohort study of college athletes to study possible associations between various GPs and prospectively occurring sports concussion. We found no significant relationship betwee. The APOE e4 allele. The APOE G-219T promoter. The tau exon 6 Ser53pro o. The tau His47Tyr GPs on prospective concussion. Additional study of other GPs and haplotype combinations is a next logical step i. The search for genetic predisposition to sports-related concussion.

Full Text

Duke Authors

Cited Authors

  • Terrell, TR; Bostick, R; Rogers, GL; Langston, MA; Barth, J; Bennett, E; Sloane, R; Galloway, L; Cantu, RC; Mihelic, FM

Published Date

  • January 1, 2014

Published In

  • Proceedings of the 2014 Biomedical Sciences and Engineering Conference 5th Annual Ornl Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations the Multi Scale Brain: Spanning Molecular, Cellular, Systems, Cognitive, Behavioral, and Clinical Neuroscience, Bsec 2014

International Standard Book Number 13 (ISBN-13)

  • 9781479941599

Digital Object Identifier (DOI)

  • 10.1109/BSEC.2014.6867745

Citation Source

  • Scopus