Antifibrinolytic Therapy and Perioperative Considerations.


Journal Article (Review)

Fibrinolysis is a physiologic component of hemostasis that functions to limit clot formation. However, after trauma or surgery, excessive fibrinolysis may contribute to coagulopathy, bleeding, and inflammatory responses. Antifibrinolytic agents are increasingly used to reduce bleeding, allogeneic blood administration, and adverse clinical outcomes. Tranexamic acid is the agent most extensively studied and used in most countries. This review will explore the role of fibrinolysis as a pathologic mechanism, review the different pharmacologic agents used to inhibit fibrinolysis, and focus on the role of tranexamic acid as a therapeutic agent to reduce bleeding in patients after surgery and trauma.

Full Text

Duke Authors

Cited Authors

  • Levy, JH; Koster, A; Quinones, QJ; Milling, TJ; Key, NS

Published Date

  • March 2018

Published In

Volume / Issue

  • 128 / 3

Start / End Page

  • 657 - 670

PubMed ID

  • 29200009

Pubmed Central ID

  • 29200009

Electronic International Standard Serial Number (EISSN)

  • 1528-1175

Digital Object Identifier (DOI)

  • 10.1097/ALN.0000000000001997


  • eng

Conference Location

  • United States