Peptidyl transferase centres of rat and yeast ribosomes. Different response to modification of protein amino groups.


Journal Article

Modification of rat liver ribosomes with dimethylmaleic anhydride, a reagent for protein amino groups, causes a large stimulation of peptidyl transferase activity assayed by the "fragment" reaction, as well as the inactivation of poly(U)-directed polyphenylalanine synthesis. In contrast to rat ribosomes, the peptidyl transferase of yeast ribosomes is little affected by modification. Although other interpretations are not excluded, these results might be due to differences between the peptidyl transferase centres of mammalian and yeast ribosomes.

Full Text

Duke Authors

Cited Authors

  • González, PJ; Hernández, F; Vioque, A; Palacián, E

Published Date

  • January 1, 1986

Published In

Volume / Issue

  • 85 / 4

Start / End Page

  • 895 - 898

PubMed ID

  • 3545662

Pubmed Central ID

  • 3545662

International Standard Serial Number (ISSN)

  • 0305-0491

Digital Object Identifier (DOI)

  • 10.1016/0305-0491(86)90193-8


  • eng