Protective effect of nifedipine against carrageenan-induced inflammation.


Journal Article

Administration of carrageenan (CA; 0.5 mg) to the plantar tissue of rats resulted in reversible inflammatory injury. The edema was monitored by changes in paw volume using a plethysmometer. Simultaneous administration of CA and nifedipine, intraperitoneally, at different doses (10, 20 and 50 mg/kg) prevented the inflammatory action, and the effect was dose- and time-dependent. In order to improve the nifedipine effects, we prepared liposomed nifedipine which, administered intraperitoneally, showed a greater anti-inflammatory action. In the presence of the L-type channel agonist Bay K 8644, the inflammation produced by CA increased and it was counteracted by free or liposomed nifedipine. The significance of these findings with respect to the mechanism of the anti-inflammatory action of nifedipine is discussed.

Full Text

Duke Authors

Cited Authors

  • Sánchez, S; Bartrons, R; Rodríguez, L; González, P; Planas, ME

Published Date

  • March 1, 1998

Published In

Volume / Issue

  • 56 / 3

Start / End Page

  • 131 - 136

PubMed ID

  • 9532612

Pubmed Central ID

  • 9532612

International Standard Serial Number (ISSN)

  • 0031-7012

Digital Object Identifier (DOI)

  • 10.1159/000028190


  • eng

Conference Location

  • Switzerland