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COMBINED AUTOLOGOUS TRANSPLANTATION OF NEUROSENSORY RETINA, RETINAL PIGMENT EPITHELIUM, AND CHOROID FREE GRAFTS.

Publication ,  Journal Article
Parolini, B; Grewal, DS; Pinackatt, SJ; Baldi, A; Di Salvatore, A; Besozzi, G; Finzi, A; Cardillo, D; Mahmoud, TH
Published in: Retina
September 2018

PURPOSE: To evaluate the feasibility and initial functional and anatomical outcomes of transplanting a full-thickness free graft of choroid and retinal pigment epithelium (RPE), along with neurosensory retina in advanced fibrosis and atrophy associated with end-stage exudative age-related macular degeneration with and without a concurrent refractory macular hole. METHODS: During vitrectomy, an RPE-choroidal and neurosensory retinal free graft was harvested in nine eyes of nine patients. The RPE-choroidal and neurosensory retinal free graft was either placed subretinally (n = 5), intraretinally to cover the foveal area inside an iatrogenically induced macular hole over the RPE-choroidal graft (n = 3) or preretinally (n = 1) without a retinotomy wherein both free grafts were placed over the concurrent macular hole. Silicone oil endotamponade was used in all cases. RESULTS: Mean follow-up was 7 ± 5.5 months (range 3-19). The mean preoperative visual acuity was ∼count fingers (logarithm of the minimum angle of resolution = 2.11, range 2-3), which improved to ∼20/800 (logarithm of the minimum angle of resolution 1.62 ± 0.48, range 0.7-2, P = 0.04). Vision was stable in 5 eyes (55.6%) and improved in 4 eyes (44.4%). Reading ability improved in 5 eyes (55.6%). Postoperative complications were graft atrophy (n = 1), epiretinal membrane (n = 1), and dislocation of neurosensory retina-choroid-RPE free graft (n = 1). CONCLUSION: Combined autologous RPE-choroid and neurosensory retinal free graft is a potential surgical alternative in eyes with end-stage exudative age-related macular degeneration, including concurrent refractory macular hole.

Duke Scholars

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Published In

Retina

DOI

EISSN

1539-2864

Publication Date

September 2018

Volume

38 Suppl 1

Issue

Suppl 1

Start / End Page

S12 / S22

Location

United States

Related Subject Headings

  • Wet Macular Degeneration
  • Vitrectomy
  • Visual Acuity
  • Treatment Outcome
  • Transplantation, Autologous
  • Time Factors
  • Retinal Pigment Epithelium
  • Retinal Perforations
  • Ophthalmology & Optometry
  • Male
 

Citation

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MLA
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Parolini, B., Grewal, D. S., Pinackatt, S. J., Baldi, A., Di Salvatore, A., Besozzi, G., … Mahmoud, T. H. (2018). COMBINED AUTOLOGOUS TRANSPLANTATION OF NEUROSENSORY RETINA, RETINAL PIGMENT EPITHELIUM, AND CHOROID FREE GRAFTS. Retina, 38 Suppl 1(Suppl 1), S12–S22. https://doi.org/10.1097/IAE.0000000000001914
Parolini, Barbara, Dilraj S. Grewal, Sajish J. Pinackatt, Andrea Baldi, Attilio Di Salvatore, Gianluca Besozzi, Alessandro Finzi, Daniele Cardillo, and Tamer H. Mahmoud. “COMBINED AUTOLOGOUS TRANSPLANTATION OF NEUROSENSORY RETINA, RETINAL PIGMENT EPITHELIUM, AND CHOROID FREE GRAFTS.Retina 38 Suppl 1, no. Suppl 1 (September 2018): S12–22. https://doi.org/10.1097/IAE.0000000000001914.
Parolini B, Grewal DS, Pinackatt SJ, Baldi A, Di Salvatore A, Besozzi G, et al. COMBINED AUTOLOGOUS TRANSPLANTATION OF NEUROSENSORY RETINA, RETINAL PIGMENT EPITHELIUM, AND CHOROID FREE GRAFTS. Retina. 2018 Sep;38 Suppl 1(Suppl 1):S12–22.
Parolini, Barbara, et al. “COMBINED AUTOLOGOUS TRANSPLANTATION OF NEUROSENSORY RETINA, RETINAL PIGMENT EPITHELIUM, AND CHOROID FREE GRAFTS.Retina, vol. 38 Suppl 1, no. Suppl 1, Sept. 2018, pp. S12–22. Pubmed, doi:10.1097/IAE.0000000000001914.
Parolini B, Grewal DS, Pinackatt SJ, Baldi A, Di Salvatore A, Besozzi G, Finzi A, Cardillo D, Mahmoud TH. COMBINED AUTOLOGOUS TRANSPLANTATION OF NEUROSENSORY RETINA, RETINAL PIGMENT EPITHELIUM, AND CHOROID FREE GRAFTS. Retina. 2018 Sep;38 Suppl 1(Suppl 1):S12–S22.

Published In

Retina

DOI

EISSN

1539-2864

Publication Date

September 2018

Volume

38 Suppl 1

Issue

Suppl 1

Start / End Page

S12 / S22

Location

United States

Related Subject Headings

  • Wet Macular Degeneration
  • Vitrectomy
  • Visual Acuity
  • Treatment Outcome
  • Transplantation, Autologous
  • Time Factors
  • Retinal Pigment Epithelium
  • Retinal Perforations
  • Ophthalmology & Optometry
  • Male