Whole-genome sequencing of bloodstream Staphylococcus aureus isolates does not distinguish bacteraemia from endocarditis.

Journal Article (Journal Article)

Most Staphylococcus aureus isolates can cause invasive disease given the right circumstances, but it is unknown if some isolates are more likely to cause severe infections than others. S. aureus bloodstream isolates from 120 patients with definite infective endocarditis and 121 with S. aureus bacteraemia without infective endocarditis underwent whole-genome sequencing. Genome-wide association analysis was performed using a variety of bioinformatics approaches including SNP analysis, accessory genome analysis and k-mer based analysis. Core and accessory genome analyses found no association with either of the two clinical groups. In this study, the genome sequences of S. aureus bloodstream isolates did not discriminate between bacteraemia and infective endocarditis. Based on our study and the current literature, it is not convincing that a specific S. aureus genotype is clearly associated to infective endocarditis in patients with S. aureus bacteraemia.

Full Text

Duke Authors

Cited Authors

  • Lilje, B; Rasmussen, RV; Dahl, A; Stegger, M; Skov, RL; Fowler, VG; Ng, KL; Kiil, K; Larsen, AR; Petersen, A; Johansen, HK; Schønheyder, HC; Arpi, M; Rosenvinge, FS; Korup, E; Høst, U; Hassager, C; Gill, SUA; Hansen, TF; Johannesen, TB; Smit, J; Søgaard, P; Skytt Andersen, P; Eske-Bruun, N

Published Date

  • November 2017

Published In

Volume / Issue

  • 3 / 11

PubMed ID

  • 29208121

Pubmed Central ID

  • PMC5729915

Electronic International Standard Serial Number (EISSN)

  • 2057-5858

Digital Object Identifier (DOI)

  • 10.1099/mgen.0.000138


  • eng

Conference Location

  • England