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Evaluation of pre- and postoperative chemotherapy for resectable adenocarcinoma of the esophagus or gastroesophageal junction.

Publication ,  Journal Article
Ajani, JA; Roth, JA; Ryan, B; McMurtrey, M; Rich, TA; Jackson, DE; Abbruzzese, JL; Levin, B; DeCaro, L; Mountain, C
Published in: J Clin Oncol
July 1990

Thirty-five consecutive patients with resectable adenocarcinoma of the esophagus or gastroesophageal junction were treated with two preoperative and three or four postoperative chemotherapy courses consisting of etoposide, fluorouracil, and cisplatin (EFP) to evaluate the rate of curative resection, clinical and pathologic response, toxic effects, and survival. One hundred thirty-seven courses with a median number of five courses (range, one to six) were administered. Preoperative EFP resulted in 17 (49%) major responses, including six patients who did not have carcinoma cells in the repeat endoscopic biopsy specimens and cytologic brushings. Among 32 patients who had surgery, 25 (78%) had curative resection, one patient had a complete pathologic response, and one had microscopic carcinoma in the resected specimen. Six patients had microscopic carcinoma at the resection margins and received postoperative radiotherapy. At a median follow-up of 20 months, the projected survival of 35 patients is 23 months (range, 6 to 33+). Fifteen patients died of their carcinomas, and 15 patients were alive (median follow-up, 20+ months; range, 15+ to 33+ months) with no evidence of relapse. There were no deaths related to chemotherapy, surgery, or radiotherapy. EFP-induced toxic reactions were moderate. Our data suggest that multiple courses of EFP are feasible. Future strategies for this disease should consider prolonged chemotherapy with regimens that result frequently in pathologic complete responses.

Duke Scholars

Published In

J Clin Oncol

DOI

ISSN

0732-183X

Publication Date

July 1990

Volume

8

Issue

7

Start / End Page

1231 / 1238

Location

United States

Related Subject Headings

  • Time Factors
  • Survival Analysis
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Humans
  • Fluorouracil
  • Female
  • Etoposide
  • Esophagogastric Junction
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ajani, J. A., Roth, J. A., Ryan, B., McMurtrey, M., Rich, T. A., Jackson, D. E., … Mountain, C. (1990). Evaluation of pre- and postoperative chemotherapy for resectable adenocarcinoma of the esophagus or gastroesophageal junction. J Clin Oncol, 8(7), 1231–1238. https://doi.org/10.1200/JCO.1990.8.7.1231
Ajani, J. A., J. A. Roth, B. Ryan, M. McMurtrey, T. A. Rich, D. E. Jackson, J. L. Abbruzzese, B. Levin, L. DeCaro, and C. Mountain. “Evaluation of pre- and postoperative chemotherapy for resectable adenocarcinoma of the esophagus or gastroesophageal junction.J Clin Oncol 8, no. 7 (July 1990): 1231–38. https://doi.org/10.1200/JCO.1990.8.7.1231.
Ajani JA, Roth JA, Ryan B, McMurtrey M, Rich TA, Jackson DE, et al. Evaluation of pre- and postoperative chemotherapy for resectable adenocarcinoma of the esophagus or gastroesophageal junction. J Clin Oncol. 1990 Jul;8(7):1231–8.
Ajani, J. A., et al. “Evaluation of pre- and postoperative chemotherapy for resectable adenocarcinoma of the esophagus or gastroesophageal junction.J Clin Oncol, vol. 8, no. 7, July 1990, pp. 1231–38. Pubmed, doi:10.1200/JCO.1990.8.7.1231.
Ajani JA, Roth JA, Ryan B, McMurtrey M, Rich TA, Jackson DE, Abbruzzese JL, Levin B, DeCaro L, Mountain C. Evaluation of pre- and postoperative chemotherapy for resectable adenocarcinoma of the esophagus or gastroesophageal junction. J Clin Oncol. 1990 Jul;8(7):1231–1238.

Published In

J Clin Oncol

DOI

ISSN

0732-183X

Publication Date

July 1990

Volume

8

Issue

7

Start / End Page

1231 / 1238

Location

United States

Related Subject Headings

  • Time Factors
  • Survival Analysis
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Humans
  • Fluorouracil
  • Female
  • Etoposide
  • Esophagogastric Junction