Association of Vitamin D receptor Fok I polymorphism with the risk of prostate cancer: a meta-analysis.


Journal Article

Several previous studies have been reported to examine the association between Vitamin D receptor (VDR) gene Fok I polymorphism and susceptibility to prostate cancer (PCa), however the results remain inconclusive. To provide a relatively comprehensive account of the association, we searched PubMed, Embase, CNKI, and Wanfang for eligible studies and carry out this meta-analysis. A total of 27 case-control studies with 10,486 cases and 10,400 controls were included. In the overall analysis, Fok I polymorphism was not significantly associated with the susceptibility to PCa. Subgroup analyses showed that significantly association was existed in Caucasian population, the subgroup of population-based controls and the stratified group with advanced tumor.These results indicate that the VDR Fok I polymorphism might be capable of causing PCa susceptibility and could be a promising target to forecast the PCa risk for clinical practice. However further well-designed epidemiologic studies are needed to confirm this conclusion.

Full Text

Cited Authors

  • Kang, S; Zhao, Y; Liu, J; Wang, L; Zhao, G; Chen, X; Yao, A; Zhang, L; Zhang, X; Li, X

Published Date

  • November 2016

Published In

Volume / Issue

  • 7 / 47

Start / End Page

  • 77878 - 77889

PubMed ID

  • 27788484

Pubmed Central ID

  • 27788484

Electronic International Standard Serial Number (EISSN)

  • 1949-2553

International Standard Serial Number (ISSN)

  • 1949-2553

Digital Object Identifier (DOI)

  • 10.18632/oncotarget.12837


  • eng