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Incorporating patient-specific CT-based ophthalmic anatomy in modeling iodine-125 eye plaque brachytherapy dose distributions.

Publication ,  Journal Article
Tien, CJ; Astrahan, MA; Kim, JM; Materin, M; Chen, Z; Nath, R; Liu, W
Published in: Brachytherapy
2017

PURPOSE: To quantify the dosimetric impact of incorporating patient-specific CT-based models rather than the conventional stylized-standard model for eye plaque brachytherapy planning. METHODS AND MATERIALS: Plaque Simulator was used to plan 16 patients using both CT-based patient-specific eye model and stylized-standard (SS) eye models. Plaque position was initially based on the SS model and compared against their patient-specific model without changing the plaque loading pattern and seed strength. Dosimetric parameters were compared for tumor and healthy ocular structures. RESULTS: Patient-specific ocular parameters ranged from 0.40 to 1.38 of SS model values. If plaques were placed based on SS model eyelet positions, target volume receiving prescription dose (V100%) is overpredicted by 5.9% on average (max: 27%), and D95% is overpredicted by 17.2 Gy on average (max: 58.1 Gy). If the plaques were recentered, 13 of 16 patients had changes in V100% of less than 2%, whereas half of the patients still had optic disc dose difference greater than 5 Gy (max: 36.2 Gy). The largest differences were observed with a target-to-optic disk distance less than 6 mm. No substantial dose differences were observed for the tumor apex, fovea, lens, and opposing retina. CONCLUSIONS: Patient-specific modeling is recommended for clinical planning, especially with target-to-optic disk distances less than 6 mm, due to significant differences compared with SS model.

Duke Scholars

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Published In

Brachytherapy

DOI

EISSN

1873-1449

Publication Date

2017

Volume

16

Issue

5

Start / End Page

1057 / 1064

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Radiotherapy Planning, Computer-Assisted
  • Radiotherapy Dosage
  • Ophthalmoscopy
  • Oncology & Carcinogenesis
  • Iodine Radioisotopes
  • Humans
  • Eye Neoplasms
  • Brachytherapy
  • 3202 Clinical sciences
 

Citation

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MLA
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Tien, C. J., Astrahan, M. A., Kim, J. M., Materin, M., Chen, Z., Nath, R., & Liu, W. (2017). Incorporating patient-specific CT-based ophthalmic anatomy in modeling iodine-125 eye plaque brachytherapy dose distributions. Brachytherapy, 16(5), 1057–1064. https://doi.org/10.1016/j.brachy.2017.06.014
Tien, Christopher J., Melvin A. Astrahan, Jenna M. Kim, Miguel Materin, Zhe Chen, Ravinder Nath, and Wu Liu. “Incorporating patient-specific CT-based ophthalmic anatomy in modeling iodine-125 eye plaque brachytherapy dose distributions.Brachytherapy 16, no. 5 (2017): 1057–64. https://doi.org/10.1016/j.brachy.2017.06.014.
Tien CJ, Astrahan MA, Kim JM, Materin M, Chen Z, Nath R, et al. Incorporating patient-specific CT-based ophthalmic anatomy in modeling iodine-125 eye plaque brachytherapy dose distributions. Brachytherapy. 2017;16(5):1057–64.
Tien, Christopher J., et al. “Incorporating patient-specific CT-based ophthalmic anatomy in modeling iodine-125 eye plaque brachytherapy dose distributions.Brachytherapy, vol. 16, no. 5, 2017, pp. 1057–64. Pubmed, doi:10.1016/j.brachy.2017.06.014.
Tien CJ, Astrahan MA, Kim JM, Materin M, Chen Z, Nath R, Liu W. Incorporating patient-specific CT-based ophthalmic anatomy in modeling iodine-125 eye plaque brachytherapy dose distributions. Brachytherapy. 2017;16(5):1057–1064.
Journal cover image

Published In

Brachytherapy

DOI

EISSN

1873-1449

Publication Date

2017

Volume

16

Issue

5

Start / End Page

1057 / 1064

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Radiotherapy Planning, Computer-Assisted
  • Radiotherapy Dosage
  • Ophthalmoscopy
  • Oncology & Carcinogenesis
  • Iodine Radioisotopes
  • Humans
  • Eye Neoplasms
  • Brachytherapy
  • 3202 Clinical sciences