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Myeloid Neoplasms Following Solid Organ Transplantation: Clinicopathologic Studies of 23 Cases.

Publication ,  Conference
Wu, B; Ingersoll, K; Jug, R; Yang, L-H; Luedke, C; Lo, A; Su, P; Liu, X; Rehder, C; Gong, J; Lu, CM; Wang, E
Published in: American journal of clinical pathology
December 2017

Myeloid neoplasms (MNs) after solid organ transplant are rare, and their clinicopathologic features have not been well characterized.We retrospectively analyzed 23 such cases.The ages ranged from 2 to 76 years, with a median of 59 years at the diagnosis. The median interval between the transplant and diagnosis was 56 months (range, 8-384 months). The transplanted organs included liver in five, kidney in six, lung in five, heart in six, and heart/lung in one case(s). The types of MN included acute myeloid leukemia (AML) in 12, myelodysplastic syndrome (MDS) in five, chronic myelogenous leukemia (CML) in four, and myeloproliferative neoplasms (MPNs) in two cases. Cytogenetics demonstrated clonal abnormalities in 18 (78.3%) cases, including unbalanced changes in 10 (55.6%), Philadelphia chromosome in four (22.2%), and other balanced aberrations in four (22.2%) cases. Thirteen (56.5%) patients died, with an estimated median survival of 9 months. With disease stratification, AML and MDS have short median survivals (3.5 and 7 months, respectively), with an initial precipitous decline of the survival curve.Posttransplant MNs have a latency period between that seen in AML/MDS related to alkylators and that associated with topoisomerase II inhibitors. The cytogenetic profile suggests a mutagenic effect on leukemogenesis. The clinical outcome for AML/MDS is dismal, with death occurring at an early phase of treatment.

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Published In

American journal of clinical pathology

DOI

EISSN

1943-7722

ISSN

0002-9173

Publication Date

December 2017

Volume

149

Issue

1

Start / End Page

55 / 66

Related Subject Headings

  • Retrospective Studies
  • Pathology
  • Organ Transplantation
  • Myocardium
  • Myeloproliferative Disorders
  • Myelodysplastic Syndromes
  • Mutation
  • Middle Aged
  • Lung
  • Liver
 

Citation

APA
Chicago
ICMJE
MLA
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Wu, B., Ingersoll, K., Jug, R., Yang, L.-H., Luedke, C., Lo, A., … Wang, E. (2017). Myeloid Neoplasms Following Solid Organ Transplantation: Clinicopathologic Studies of 23 Cases. In American journal of clinical pathology (Vol. 149, pp. 55–66). https://doi.org/10.1093/ajcp/aqx133
Wu, Bin, Kimberly Ingersoll, Rachel Jug, Lian-He Yang, Catherine Luedke, Amanda Lo, Pu Su, et al. “Myeloid Neoplasms Following Solid Organ Transplantation: Clinicopathologic Studies of 23 Cases.” In American Journal of Clinical Pathology, 149:55–66, 2017. https://doi.org/10.1093/ajcp/aqx133.
Wu B, Ingersoll K, Jug R, Yang L-H, Luedke C, Lo A, et al. Myeloid Neoplasms Following Solid Organ Transplantation: Clinicopathologic Studies of 23 Cases. In: American journal of clinical pathology. 2017. p. 55–66.
Wu, Bin, et al. “Myeloid Neoplasms Following Solid Organ Transplantation: Clinicopathologic Studies of 23 Cases.American Journal of Clinical Pathology, vol. 149, no. 1, 2017, pp. 55–66. Epmc, doi:10.1093/ajcp/aqx133.
Wu B, Ingersoll K, Jug R, Yang L-H, Luedke C, Lo A, Su P, Liu X, Rehder C, Gong J, Lu CM, Wang E. Myeloid Neoplasms Following Solid Organ Transplantation: Clinicopathologic Studies of 23 Cases. American journal of clinical pathology. 2017. p. 55–66.
Journal cover image

Published In

American journal of clinical pathology

DOI

EISSN

1943-7722

ISSN

0002-9173

Publication Date

December 2017

Volume

149

Issue

1

Start / End Page

55 / 66

Related Subject Headings

  • Retrospective Studies
  • Pathology
  • Organ Transplantation
  • Myocardium
  • Myeloproliferative Disorders
  • Myelodysplastic Syndromes
  • Mutation
  • Middle Aged
  • Lung
  • Liver